Envelope protein E/E protein (TBEV)

Tick-borne encephalitis virus (TBEV), which belongs to Family Flaviviridae, is the leading cause of Tick-borne encephalitis in human and animals across Europe and East Asia. The infection of TBE virus will lead to the illness called Tick-borne encephalitis with high morbidity and mortality. TBE virus has three regional subtypes of European subtype (TBEV-Eu), Far-eastern subtype TBEV (TBEV-FE) and Siberian subtype (TBEV-Sib) that dominate their respective regions; however, the sequence variety at amino acid level is quite low and the European subtypes’ vaccines show cross protection against other subtypes. The envelope protein E is the major viral surface antigen that plays an important role in viral infection, making it a great target for vaccine development.