언어 선택

Endoglin

Endoglin 분자 정보

영어 이름	Endoglin	시판 약물 수	0
임상 약물 수	2	표적 별명	CD105 Antigen，CD105，END，ENG，Osler-Rendu-Weber Syndrome 1，HHT1，ORW1，Endoglin
최고 연구 개발 단계	Phase 2 Clinical

영어 이름	Endoglin
표적 별명	CD105 Antigen，CD105，END，ENG，Osler-Rendu-Weber Syndrome 1，HHT1，ORW1，Endoglin
시판 약물 수	0
임상 약물 수	2
최고 연구 개발 단계	Phase 2 Clinical

Endoglin 제품 목록

속성
Protein (1)
제품 라이브러리
온라인 (1)
종
Human (1)
태그
His Tag (1)
마커
Unconjugated (1)

제품 번호	종	발현 시스템	제품 설명	단백질 구조	순도	특성
ENN-H52H9	Human	HEK293	Human Endoglin / CD105 Protein, His Tag

총 수량1

Endoglin분자 배경

Endoglin (ENG), endothelial glycoprotein, also known as CD105, is a coreceptor of the transforming growth factor-β (TGFβ) family signaling complex, which is highly expressed on endothelial cells and plays a key role in angiogenesis. It regulates the responses associated with binding to transforming growth factor β1 egg (Activin-A), bone morphogenetic protein 2 (BMP-2), and bone morphogenetic protein 7 (BMP-7). Endoglin may be involved in autosomal dominant disease, such as hereditary hemorrhagic telangiectasia 1 (HHT1). Circulating soluble ENG is also elevated in pulmonary arterial hypertension(PAH) and is proposed to be a biomarker for the prognosis of group I PAH patients.

Endoglin분자 별명

Endoglin,CD105,ENG,END

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
Carotuximab	DE-122; TRC-105; NSC#754227; Chimeric Antibody TRC-105; ENV-105	Phase 2 Clinical	Roswell Park Cancer Institute	Adenoma, Liver Cell; Astrocytoma; Brain Neoplasms; Breast Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Choriocarcinoma; Fallopian Tube Neoplasms; Gestational Trophoblastic Disease; Glioblastoma; Glioma; Gliosarcoma; Hemangiosarcoma; Liver Neoplasms; Liver Neoplasms, Experimental; Lung Neoplasms; Macular Degeneration; Metastatic breast cancer; Neoplasm Metastasis; Neoplasms; Oligodendroglioma; Ovarian Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Sarcoma; Solid tumours; Trophoblastic Neoplasms; Trophoblastic Tumor, Placental Site; Ureteral Neoplasms	상세
STEMVAC	EP-101	Phase 2 Clinical	Epithany	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; HR-positive breast cancer; Lung Neoplasms; Triple Negative Breast Neoplasms	상세