언어 선택

E-Cadherin

E-Cadherin 분자 정보

영어 이름	Cadherin-1	시판 약물 수	0
임상 약물 수	0	표적 별명	CAM 120/80，Epithelial cadherin，Ecad，Uvomorulin，CDHE，UVO
최고 연구 개발 단계	Preclinical

영어 이름	Cadherin-1
표적 별명	CAM 120/80，Epithelial cadherin，Ecad，Uvomorulin，CDHE，UVO
시판 약물 수	0
임상 약물 수	0
최고 연구 개발 단계	Preclinical

E-Cadherin 제품 목록

속성
Protein (2)Antibody (1)
제품 라이브러리
온라인 (3)
종
Human (2)Mouse (1)
태그
Fc Tag (2)- (1)
마커
Unconjugated (3)

제품 번호	종	발현 시스템	제품 설명
ECD-H5250	Human	HEK293	Human E-Cadherin / Cadherin-1 Protein, Fc Tag, premium grade
ECD-H5256	Human	HEK293	Human E-Cadherin / Cadherin-1 (155-709) Protein, Fc Tag (MALS verified)
HGS-S590	Mouse	-	Recombinant Monoclonal Anti-E-Cadherin Antibody, Mouse (3F7)

총 수량3

E-Cadherin분자 배경

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Cadherin-1 (CDH1) is also known as epithelial cadherin (E-cadherin), CD_antigen (CD324), Uvomorulin (UVO) ECAD and CDHE, CDH1 / CD324 contains 5 cadherin domains. CDH1 / CD324 / ECAD is expressed in non-neural epithelial tissues. CDH1 / E-CAD is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells and has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. E-Cad promotes non-amyloidogenic degradation of Abeta precursors and has a strong inhibitory effect on APP C99 and C83 production. Defects in CDH1 / CD324 / ECAD are the cause of hereditary diffuse gastric cancer (HDGC).