언어 선택

Dkk-3

Dkk-3 분자 정보

영어 이름	Dickkopf-related protein 3	시판 약물 수	0
임상 약물 수	1	표적 별명	Dickkopf 3 Homolog (Xenopus Laevis)，UNQ258/PRO295，Dickkopf-3，Dickkopf-related protein 3，hDkk-3，REIC，DKK3，Dickkopf WNT Signaling Pathway Inhibitor 3，Regulated In Glioma，Dkk-3，Dickkopf (Xenopus Laevis) Homolog 3，Dickkopf 3 Homolog，Dickkopf Homolog 3，RIG-Like 5-6，RIG-Like 7-1，RIG
최고 연구 개발 단계	Phase 2 Clinical

영어 이름	Dickkopf-related protein 3
표적 별명	Dickkopf 3 Homolog (Xenopus Laevis)，UNQ258/PRO295，Dickkopf-3，Dickkopf-related protein 3，hDkk-3，REIC，DKK3，Dickkopf WNT Signaling Pathway Inhibitor 3，Regulated In Glioma，Dkk-3，Dickkopf (Xenopus Laevis) Homolog 3，Dickkopf 3 Homolog，Dickkopf Homolog 3，RIG-Like 5-6，RIG-Like 7-1，RIG
시판 약물 수	0
임상 약물 수	1
최고 연구 개발 단계	Phase 2 Clinical

Dkk-3 제품 목록

속성
Protein (2)
제품 라이브러리
온라인 (2)
종
Human (1)Mouse (1)
태그
His Tag (2)
마커
Unconjugated (2)

제품 번호	종	발현 시스템	제품 설명	단백질 구조	순도	특성
DK3-H5220	Human	HEK293	Human Dkk-3 (R335G) Protein, His Tag
DK3-M5226	Mouse	HEK293	Mouse Dkk-3 Protein, His Tag

총 수량2

Dkk-3분자 배경

Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK3 has been proposed as tumour suppressor gene and a marker for tumour blood vessels. DKK3 is the only DKK family member abundantly expressed in normal lung, but silenced by promoter hypermethylation in a large fraction of lung cancer cell lines and lung tumors. Downregulation of DKK3 was correlated with tumor progression and expression of nuclear beta-catenin in lung tumors. Ectopic expression of DKK3 in lung cancer cells with DKK3 hypermethylation induced apoptosis and inhibited TCF-4 activity as well as nuclear accumulation of beta-catenin and expression of TCF-4 targets c-Myc and cyclin D1. DKK3 modulates FGF and Activin/Nodal signaling to regulate mesoderm induction during early Xenopus development, was reported.