언어 선택

DDR1

DDR1 분자 정보

영어 이름	Discoidin domain receptor 1	시판 약물 수	0
임상 약물 수	5	표적 별명	Epithelial discoidin domain-containing receptor 1，Epithelial discoidin domain receptor 1，CD167 antigen-like family member A，Cell adhesion kinase，Discoidin receptor tyrosine kinase，HGK2，Mammary carcinoma kinase 10，MCK-10，Protein-tyrosine kinase 3A，Protein-tyrosine kinase RTK-6，TRK E，Tyrosine kinase DDR，Tyrosine-protein kinase CAK，CD167a，CD167 Antigen-Like Family Member A，TRKE，RTK6，PTK3A Protein Tyrosine Kinase 3A，PTK3A，NTRK4，Neurotrophic Tyrosine Kinase， Receptor， Type 4，Neuroepithelial Tyrosine Kinase，NEP，MCK10，EDDR1，Discoidin Domain Receptor Tyrosine Kinase 1，Discoidin Domain Receptor Family， Member 1，CD167a Antigen，CAK，CD167
최고 연구 개발 단계	Phase 2 Clinical

영어 이름	Discoidin domain receptor 1
표적 별명	Epithelial discoidin domain-containing receptor 1，Epithelial discoidin domain receptor 1，CD167 antigen-like family member A，Cell adhesion kinase，Discoidin receptor tyrosine kinase，HGK2，Mammary carcinoma kinase 10，MCK-10，Protein-tyrosine kinase 3A，Protein-tyrosine kinase RTK-6，TRK E，Tyrosine kinase DDR，Tyrosine-protein kinase CAK，CD167a，CD167 Antigen-Like Family Member A，TRKE，RTK6，PTK3A Protein Tyrosine Kinase 3A，PTK3A，NTRK4，Neurotrophic Tyrosine Kinase， Receptor， Type 4，Neuroepithelial Tyrosine Kinase，NEP，MCK10，EDDR1，Discoidin Domain Receptor Tyrosine Kinase 1，Discoidin Domain Receptor Family， Member 1，CD167a Antigen，CAK，CD167
시판 약물 수	0
임상 약물 수	5
최고 연구 개발 단계	Phase 2 Clinical

DDR1 제품 목록

속성
Protein (3)
제품 라이브러리
온라인 (3)
종
Human (2)Mouse (1)
태그
Fc Tag (2)His Tag & Avi Tag (1)
마커
Unconjugated (2)Biotin-labeled (1)

제품 번호	종	발현 시스템	제품 설명
HOT DD1-H82E9	Human	HEK293	Biotinylated Human DDR1 Protein, His,Avitag™ (MALS verified)
DD1-H5258	Human	HEK293	Human DDR1 Protein, Fc Tag
DD1-M5259	Mouse	HEK293	Mouse DDR1 Protein, Fc Tag

총 수량3

DDR1분자 배경

Discoidin domain receptor 1 (DDR1) is a member of DDRs, which are members of the receptor tyrosine kinase (RTK). Upon collagen binding, DDR1 undergoes tyrosine autophosphorylation, which consequently triggers downstream genetic and cellular pathways and plays critical roles in the regulation of cellular morphogenesis, differentiation, proliferation, adhesion, migration, and invasion. Research shows that DDR1 is closely related to various human diseases including cancer, fibrosis, atherosclerosis, and other inflammatory disorders. New generation DDR1 inhibitors targeting the allosteric sites outside of the canonical ATP-binding pocket or extracellular domain (allosteric inhibitors) may offer a new opportunity for selective DDR1 inhibition therapy development.

DDR1분자 별명

CD167a

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
Merestinib	5OGS5K699E; LY-2801653	Phase 2 Clinical	Eli Lilly And Company	Biliary Tract Neoplasms; Bone metastases; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cholangiocarcinoma; Colorectal Neoplasms; Gallbladder Neoplasms; Leukemia, Myeloid, Acute; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Microsatellite instability-high cancer; Neoplasm Metastasis; Neoplasms; Pancreatic Neoplasms; Skin Melanoma; Solid tumours	상세
Ensavatatug	PRTH-101	Phase 1 Clinical	Parthenon Therapeutics Inc, The George Washington University Milken Institute School Of Public Health (Gwu)	Carcinoma, Non-Small-Cell Lung; Neoplasms; Solid tumours	상세
ICP-033	ICP-033	Phase 1 Clinical	Beijing Innocare Pharma Tech Co Ltd	Solid tumours	상세
AVI-4015	AVI-4015	Phase 1 Clinical	Avixgen	Dry Eye Syndromes	상세
AGX-0073	AGX-0073	Phase 1 Clinical	Shanghai Aojian Biological Technology Co Ltd	Solid tumours	상세