DDR1
DDR1 분자 정보
| 영어 이름 | Discoidin domain receptor 1 | 시판 약물 수 | 0 |
| 임상 약물 수 | 5 | 표적 별명 | Epithelial discoidin domain-containing receptor 1，Epithelial discoidin domain receptor 1，CD167 antigen-like family member A，Cell adhesion kinase，Discoidin receptor tyrosine kinase，HGK2，Mammary carcinoma kinase 10，MCK-10，Protein-tyrosine kinase 3A，Protein-tyrosine kinase RTK-6，TRK E，Tyrosine kinase DDR，Tyrosine-protein kinase CAK，CD167a，CD167 Antigen-Like Family Member A，TRKE，RTK6，PTK3A Protein Tyrosine Kinase 3A，PTK3A，NTRK4，Neurotrophic Tyrosine Kinase， Receptor， Type 4，Neuroepithelial Tyrosine Kinase，NEP，MCK10，EDDR1，Discoidin Domain Receptor Tyrosine Kinase 1，Discoidin Domain Receptor Family， Member 1，CD167a Antigen，CAK，CD167 |
| 최고 연구 개발 단계 | Phase 2 Clinical | ||
| 영어 이름 | Discoidin domain receptor 1 |
| 표적 별명 | Epithelial discoidin domain-containing receptor 1，Epithelial discoidin domain receptor 1，CD167 antigen-like family member A，Cell adhesion kinase，Discoidin receptor tyrosine kinase，HGK2，Mammary carcinoma kinase 10，MCK-10，Protein-tyrosine kinase 3A，Protein-tyrosine kinase RTK-6，TRK E，Tyrosine kinase DDR，Tyrosine-protein kinase CAK，CD167a，CD167 Antigen-Like Family Member A，TRKE，RTK6，PTK3A Protein Tyrosine Kinase 3A，PTK3A，NTRK4，Neurotrophic Tyrosine Kinase， Receptor， Type 4，Neuroepithelial Tyrosine Kinase，NEP，MCK10，EDDR1，Discoidin Domain Receptor Tyrosine Kinase 1，Discoidin Domain Receptor Family， Member 1，CD167a Antigen，CAK，CD167 |
| 시판 약물 수 | 0 |
| 임상 약물 수 | 5 |
| 최고 연구 개발 단계 | Phase 2 Clinical |
DDR1 제품 목록
- 속성
Protein (3)
- 제품 라이브러리
온라인 (3)
- 종
Human (2)Mouse (1)
- 태그
Fc Tag (2)His Tag & Avi Tag (1)
- 마커
Unconjugated (2)Biotin-labeled (1)
| 제품 번호 | 종 | 발현 시스템 | 제품 설명 | 단백질 구조 | 순도 | 특성 |
|---|---|---|---|---|---|---|
 Human | HEK293 | Biotinylated Human DDR1 Protein, His,Avitag™ (MALS & BLI verified) |  |  |  | |
| Human | HEK293 | Human DDR1 Protein, Fc Tag (BLI verified) |  | | | |
 Mouse | HEK293 | Mouse DDR1 Protein, Fc Tag |  | |  |
총 수량3
- 1
DDR1분자 배경
Discoidin domain receptor 1 (DDR1) is a member of DDRs, which are members of the receptor tyrosine kinase (RTK). Upon collagen binding, DDR1 undergoes tyrosine autophosphorylation, which consequently triggers downstream genetic and cellular pathways and plays critical roles in the regulation of cellular morphogenesis, differentiation, proliferation, adhesion, migration, and invasion. Research shows that DDR1 is closely related to various human diseases including cancer, fibrosis, atherosclerosis, and other inflammatory disorders. New generation DDR1 inhibitors targeting the allosteric sites outside of the canonical ATP-binding pocket or extracellular domain (allosteric inhibitors) may offer a new opportunity for selective DDR1 inhibition therapy development.
DDR1분자 별명
CD167a
임상 약물 정보
| 영어 이름 | 연구 코드 | 연구 개발 단계 | 회사 | 적응증 | 임상 시험 |
|---|---|---|---|---|---|
| Merestinib | 5OGS5K699E; LY-2801653 | Phase 2 Clinical | Eli Lilly And Company | Biliary Tract Neoplasms; Bone metastases; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cholangiocarcinoma; Colorectal Neoplasms; Gallbladder Neoplasms; Leukemia, Myeloid, Acute; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Microsatellite instability-high cancer; Neoplasm Metastasis; Neoplasms; Pancreatic Neoplasms; Skin Melanoma; Solid tumours | 상세 |
| Ensavatatug | PRTH-101 | Phase 1 Clinical | Parthenon Therapeutics Inc, The George Washington University Milken Institute School Of Public Health (Gwu) | Carcinoma, Non-Small-Cell Lung; Neoplasms; Solid tumours | 상세 |
| ICP-033 | ICP-033 | Phase 1 Clinical | Beijing Innocare Pharma Tech Co Ltd | Solid tumours | 상세 |
| AVI-4015 | AVI-4015 | Phase 1 Clinical | Avixgen | Dry Eye Syndromes | 상세 |
| AGX-0073 | AGX-0073 | Phase 1 Clinical | Shanghai Aojian Biological Technology Co Ltd | Solid tumours | 상세 |
- 분자 정보
- 제품 목록
- 임상 약물 정보