언어 선택

CXCR3

CXCR3 분자 정보

영어 이름	C-X-C motif chemokine receptor 3	시판 약물 수	0
임상 약물 수	2	표적 별명	CKR-L2，G protein-coupled receptor 9，IP-10 receptor，CXCR-3，CXC-R3，CXCR3，C-X-C Motif Chemokine Receptor 3，Interferon-Inducible Protein 10 Receptor，GPR9，C-X-C Chemokine Receptor Type 3，Chemokine Receptor 3，CD183 Antigen，CMKAR3，Chemokine (C-X-C Motif) Receptor 3，Mig Receptor，IP10-R，CD182，CD183，Mig-R，MigR，Receptors， CXCR3
최고 연구 개발 단계	Phase 1 Clinical

영어 이름	C-X-C motif chemokine receptor 3
표적 별명	CKR-L2，G protein-coupled receptor 9，IP-10 receptor，CXCR-3，CXC-R3，CXCR3，C-X-C Motif Chemokine Receptor 3，Interferon-Inducible Protein 10 Receptor，GPR9，C-X-C Chemokine Receptor Type 3，Chemokine Receptor 3，CD183 Antigen，CMKAR3，Chemokine (C-X-C Motif) Receptor 3，Mig Receptor，IP10-R，CD182，CD183，Mig-R，MigR，Receptors， CXCR3
시판 약물 수	0
임상 약물 수	2
최고 연구 개발 단계	Phase 1 Clinical

CXCR3 제품 목록

속성
Protein (4)Cell (2)
제품 라이브러리
온라인 (6)
종
Human (5)Mouse (1)
태그
- (5)His Tag & Flag Tag (1)
마커
Unconjugated (3)- (2)Biotin-labeled (1)

제품 번호	종	발현 시스템	제품 설명
HOT CX3-H52D5	Human	HEK293	Human CXCR3 Protein, Flag,His Tag (Detergent)
CCHO-ATP252	Human	CHO	CHO/Human CXCR3 Stable Cell Line
CHEK-ATP253	Human	HEK293	HEK293/Human CXCR3 Stable Cell Line
CX3-H52P4	Human	HEK293	Human CXCR3 Full Length Protein (VLP)
CX3-H82P3	Human	HEK293	Biotinylated Human CXCR3 Full Length Protein (VLP)
CX3-M52P7	Mouse	HEK293	Mouse CXCR3 Full Length Protein (VLP)

총 수량6

CXCR3분자 배경

Chemokines are proteins which induce chemotaxis, promote differentiation of immune cells, and cause tissue extravasation. Given these properties, their role in anti-tumor immune response in the cancer environment is of great interest. Although immunotherapy has shown clinical benefit for some cancer patients, other patients do not respond. One of the mechanisms of resistance to checkpoint inhibitors may be chemokine signaling. The CXCL9, -10, -11/CXCR3 axis regulates immune cell migration, differentiation, and activation, leading to tumor suppression (paracrine axis). However, there are some reports that show involvements of this axis in tumor growth and metastasis (autocrine axis). Thus, a better understanding of CXCL9, -10, -11/CXCR3 axis is necessary to develop effective cancer control.

CXCR3분자 별명

CD182, CD183, CKR-L2, CMKAR3, GPR9, IP10-R, Mig-R, MigR

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
OCU-110	OCU-10-C-110; OGX-110; OCU-110	Phase 1 Clinical	Ocugenix Corp	Macular Degeneration	상세
ACT-777991	ACT-777991	Phase 1 Clinical	Idorsia Pharmaceuticals Ltd	Diabetes Mellitus, Type 1; Inflammation	상세