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CXCR3

CXCR3 Overview

English Name	C-X-C motif chemokine receptor 3	Approved Drugs	0
Drugs in Clinical Trials	2	Target Synonym	CKR-L2，G protein-coupled receptor 9，IP-10 receptor，CXCR-3，CXC-R3，CXCR3，C-X-C Motif Chemokine Receptor 3，Interferon-Inducible Protein 10 Receptor，GPR9，C-X-C Chemokine Receptor Type 3，Chemokine Receptor 3，CD183 Antigen，CMKAR3，Chemokine (C-X-C Motif) Receptor 3，Mig Receptor，IP10-R，CD182，CD183，Mig-R，MigR，Receptors， CXCR3
Highest Development Stage	Phase 1 Clinical

English Name	C-X-C motif chemokine receptor 3
Target Synonym	CKR-L2，G protein-coupled receptor 9，IP-10 receptor，CXCR-3，CXC-R3，CXCR3，C-X-C Motif Chemokine Receptor 3，Interferon-Inducible Protein 10 Receptor，GPR9，C-X-C Chemokine Receptor Type 3，Chemokine Receptor 3，CD183 Antigen，CMKAR3，Chemokine (C-X-C Motif) Receptor 3，Mig Receptor，IP10-R，CD182，CD183，Mig-R，MigR，Receptors， CXCR3
Approved Drugs	0
Drugs in Clinical Trials	2
Highest Development Stage	Phase 1 Clinical

CXCR3 Product List

Product Category
Protein (4)Cell (2)
Product Status
Launched (6)
Species
Human (5)Mouse (1)
Tag
- (5)His Tag & Flag Tag (1)
Conjugate
Unconjugated (3)- (2)Biotin-labeled (1)

Cat. No.	Species	Host	Product Description
HOT AI Compatible CX3-H52D5	Human	HEK293	Human CXCR3 Protein, Flag,His Tag (Detergent)
CCHO-ATP252	Human	CHO	CHO/Human CXCR3 Stable Cell Line
AI Compatible CHEK-ATP253	Human	HEK293	HEK293/Human CXCR3 Stable Cell Line
AI Compatible CX3-H52P4	Human	HEK293	Human CXCR3 Full Length Protein (VLP)
AI Compatible CX3-H82P3	Human	HEK293	Biotinylated Human CXCR3 Full Length Protein (VLP)
AI Compatible CX3-M52P7	Mouse	HEK293	Mouse CXCR3 Full Length Protein (VLP)

Total: 6

CXCR3 Background

Chemokines are proteins which induce chemotaxis, promote differentiation of immune cells, and cause tissue extravasation. Given these properties, their role in anti-tumor immune response in the cancer environment is of great interest. Although immunotherapy has shown clinical benefit for some cancer patients, other patients do not respond. One of the mechanisms of resistance to checkpoint inhibitors may be chemokine signaling. The CXCL9, -10, -11/CXCR3 axis regulates immune cell migration, differentiation, and activation, leading to tumor suppression (paracrine axis). However, there are some reports that show involvements of this axis in tumor growth and metastasis (autocrine axis). Thus, a better understanding of CXCL9, -10, -11/CXCR3 axis is necessary to develop effective cancer control.

CXCR3 Synonyms

CD182, CD183, CKR-L2, CMKAR3, GPR9, IP10-R, Mig-R, MigR

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
OCU-110	OCU-10-C-110; OGX-110; OCU-110	Phase 1 Clinical	Ocugenix Corp	Macular Degeneration	Details
ACT-777991	ACT-777991	Phase 1 Clinical	Idorsia Pharmaceuticals Ltd	Diabetes Mellitus, Type 1; Inflammation	Details