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CXCL9

CXCL9 Overview

English Name	C-X-C motif chemokine 9	Approved Drugs	0
Drugs in Clinical Trials	1	Target Synonym	C-X-C motif chemokine 9，Gamma-interferon-induced monokine，Monokine induced by interferon-gamma (HuMIG; MIG)，Small-inducible cytokine B9，SCYB9，Crg-10，Humig，CMK，MIG，Monokine Induced By Gamma Interferon，Monokine Induced By Interferon-Gamma，Gamma-Interferon-Induced Monokine，Chemokine (C-X-C Motif) Ligand 9，Small-Inducible Cytokine B9，C-X-C Motif Chemokine 9，HuMIG
Highest Development Stage	Phase 1 Clinical

English Name	C-X-C motif chemokine 9
Target Synonym	C-X-C motif chemokine 9，Gamma-interferon-induced monokine，Monokine induced by interferon-gamma (HuMIG; MIG)，Small-inducible cytokine B9，SCYB9，Crg-10，Humig，CMK，MIG，Monokine Induced By Gamma Interferon，Monokine Induced By Interferon-Gamma，Gamma-Interferon-Induced Monokine，Chemokine (C-X-C Motif) Ligand 9，Small-Inducible Cytokine B9，C-X-C Motif Chemokine 9，HuMIG
Approved Drugs	0
Drugs in Clinical Trials	1
Highest Development Stage	Phase 1 Clinical

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CXCL9 Background

CXCL9 is a small cytokine belonging to the CXC chemokine family that is also known as monokine induced by gamma interferon (MIG). CXCL9 is a chemokine that plays a role in immune responses, it can induce chemotaxis, promote differentiation and proliferation of leukocytes, and cause tissue extravasation. CXCL9 regulates immune cell migration, differentiation and activation by binding to CXCR3 receptor, such as CTLs, NK cells, NKT cells and macrophages. CXCL9 also participates in Th1 polarization and IFN-γ response.

CXCL9 Synonyms

CMK, Humig, MIG, SCYB9, crg-10

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
NG-641	EnAd-FAP-BiTE; EnAd-FAP-Tac; NG-641; NG-aFAP	Phase 1 Clinical	Akamis Bio Ltd, University Of Oxford	Squamous Cell Carcinoma of Head and Neck; Neoplasms, Glandular and Epithelial; Neoplasm Metastasis	Details