언어 선택

CXADR

CXADR 분자 정보

영어 이름	Calcium sensing receptor	시판 약물 수	6
임상 약물 수	5	표적 별명	Parathyroid cell calcium-sensing receptor 1，FHH，FIH，HHC，Receptors， Calcium-Sensing，Extracellular calcium-sensing receptor，hCasR，GPRC2A，Calcium Sensing Receptor，Parathyroid Ca(2+)-Sensing Receptor 1，Severe Neonatal Hyperparathyroidism，Calcium-Sensing Receptor，HYPOC1，NSHPT，PCaR1，EIG8，HHC1，CaSR，CAR，Hypocalciuric Hypercalcemia 1
최고 연구 개발 단계	Approved

영어 이름	Calcium sensing receptor
표적 별명	Parathyroid cell calcium-sensing receptor 1，FHH，FIH，HHC，Receptors， Calcium-Sensing，Extracellular calcium-sensing receptor，hCasR，GPRC2A，Calcium Sensing Receptor，Parathyroid Ca(2+)-Sensing Receptor 1，Severe Neonatal Hyperparathyroidism，Calcium-Sensing Receptor，HYPOC1，NSHPT，PCaR1，EIG8，HHC1，CaSR，CAR，Hypocalciuric Hypercalcemia 1
시판 약물 수	6
임상 약물 수	5
최고 연구 개발 단계	Approved

CXADR 제품 목록

속성
Protein (1)
제품 라이브러리
온라인 (1)
종
Human (1)
태그
His Tag (1)
마커
Unconjugated (1)

제품 번호	종	발현 시스템	제품 설명	단백질 구조	순도	특성
CXR-H5222	Human	HEK293	Human CXADR / CAR Protein, His Tag

총 수량1

CXADR분자 배경

Coxsackie virus and adenovirus receptor (CXADR) is also known as CAR, is a type I transmembrane glycoprotein for group B coxsackie viruses and subgroup C adenoviruses, and belongs to the CTX family of the Ig superfamily. CAR is strongly expressed in the developing central nervous system. It functions as a homophilic and also as a heterophilic cell adhesion molecule through its interactions with extracellular matrix glycoproteins such as: fibronectin, agrin, laminin-1 and tenascin-R. Human CXADR protein contains a signal sequence, a extracellular domain (ECD) with a V type (D1) and a C2 type (D2) Iglike domain, a transmembrane segment and a intracellular domain. D1 is thought to be responsible for homodimer formation in trans within tight junctions, and is necessary and sufficient for adenovirus binding. Variants of CXADR are attached to the cell membrane by a GPI- anchor.

CXADR분자 별명

CXADR,CAR,CAR4,6,HCAR

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
Encaleret sulfate	MK-5442; JTT-305; BBP-305; CLTX-305	Phase 3 Clinical	Japan Tobacco (Hong Kong) Ltd	Osteoporosis; Hypocalcemia; Osteoporosis, Postmenopausal; Hypoparathyroidism	상세
SHR-6508	SHR-6508	Phase 3 Clinical	Shanghai Hengrui Pharmaceutical Co Ltd	Hyperparathyroidism, Secondary; Kidney Diseases; Renal Insufficiency, Chronic; Hyperparathyroidism	상세
LNP-1892	LNP-1892	Phase 2 Clinical	Lupin Ltd	Hyperparathyroidism	상세
DS-9194b	DS-9194b	Phase 1 Clinical	Daiichi Sankyo Co Ltd	Osteoporosis	상세
RT-102(Rani)	RT-102	Phase 1 Clinical	Rani Therapeutics Holdings Inc	Osteoporosis	상세

시판 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	가장 빠른 브랜드 이름	가장 빠른 승인 국가	가장 빠른 적응증	가장 빠른 승인 회사	가장 빠른 승인 날짜	적응증	임상 시험
Upacicalcet	SK-1403; AJT-240	Approved	Ajinomoto Co Inc	ウパシタ, Upasita	Japan	Hyperparathyroidism, Secondary	Sanwa Kagaku Kenkyusho Co Ltd	2021-06-23	Hyperparathyroidism, Secondary	상세
Parathyroid hormone (Shire)	SHP-634; ALX-111; 423562; NPSP-795; rhPTH (1-84); SHP-635; rhPTH-1-84; PTH (1-84); SB-423562; PTH 1-84; NPSP-558	Approved	Shire	Natpara, Preotact, Natpar	United States	Hypoparathyroidism	Nps Pharmaceuticals, Inc	2006-04-24	Osteoporosis; Bone Diseases, Endocrine; Osteoporosis, Postmenopausal; Hypocalcemia; Hypoparathyroidism; Hyperparathyroidism; Plaque psoriasis	상세
Cinacalcet Hydrochloride	AMG-073.HCl; NPS-1493; AMG-073; KRN-1493	Approved	Amgen Inc	Parareg, Sensipar, Mimpara, Regpara, 盖平, Sensipar/Mimpara	United States	Hypercalcemia; Hyperparathyroidism, Secondary	Amgen Inc	2004-03-08	Hyperparathyroidism, Secondary; Rejection of renal transplantation; Hypophosphatemia; Edema, Cardiac; Nephrosis; Renal Insufficiency; Parathyroid Neoplasms; Hypercalcemia; Kidney Diseases; Hyperparathyroidism, Primary; Prostatic Neoplasms; Osteomalacia; Renal Insufficiency, Chronic; Kidney Failure, Chronic; Hyperparathyroidism; Chronic Kidney Disease-Mineral and Bone Disorder	상세
Etelcalcetide Hydrochloride	ONO-5163; KAI-4169; AMG-416; KAI-4169-HCl	Approved	Amgen Inc	Parsabiv	EU	Hyperparathyroidism, Secondary	Amgen Europe Bv	2016-11-11	Hyperparathyroidism, Secondary; Edema, Cardiac; Renal Insufficiency, Chronic; Kidney Failure, Chronic	상세
Strontium Ranelate	S-12911; S-12911-2; FK-481	Approved	Laboratoires Servier	Osseor, Protos, Protelos, 欧思美	Mainland China	Osteoporosis, Postmenopausal	Les Laboratoires Servier	2004-09-20	Osteoporosis, Postmenopausal	상세
Evocalcet	KHK-7580; MT-4580	Approved	Mitsubishi Tanabe Pharma Corp	Orkedia	Japan	Hyperparathyroidism, Secondary	Kyowa Hakko Kirin Co Ltd	2018-03-23	Hyperparathyroidism, Secondary; Parathyroid Neoplasms; Hyperparathyroidism, Primary; Hyperparathyroidism	상세