언어 선택

Coagulation factor XI

Coagulation factor XI 분자 정보

영어 이름	Coagulation factor XI	시판 약물 수	2
임상 약물 수	30	표적 별명	EC 3.4.21，EC:3.4.21.27，FXI，F11，PTA，Coagulation Factor XI，Plasma Thromboplastin Antecedent，EC 3.4.21.27，Factor XI，Coagualtion Factor XI
최고 연구 개발 단계	Approved

영어 이름	Coagulation factor XI
표적 별명	EC 3.4.21，EC:3.4.21.27，FXI，F11，PTA，Coagulation Factor XI，Plasma Thromboplastin Antecedent，EC 3.4.21.27，Factor XI，Coagualtion Factor XI
시판 약물 수	2
임상 약물 수	30
최고 연구 개발 단계	Approved

Coagulation factor XI 제품 목록

속성
Protein (2)
제품 라이브러리
온라인 (2)
종
Human (1)Rhesus macaque (1)
태그
His Tag (2)
마커
Unconjugated (2)

제품 번호	종	발현 시스템	제품 설명	단백질 구조	순도	특성
FXI-H52H5	Human	HEK293	Human Coagulation factor XI / FXI Protein, His Tag (active enzyme)
FXI-C52H3	Rhesus macaque	HEK293	Rhesus macaque Coagulation factor XI Protein, His Tag (Pro-form)

총 수량2

Coagulation factor XI분자 배경

This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality

Coagulation factor XI분자 별명

Coagulation factor XI,FXI,PTA,F11

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
Asundexian	BAY-2433334	Phase 3 Clinical	Bayer AG	Atrial Fibrillation; Embolism; Hepatic Insufficiency; Ischemic Attack, Transient; Ischemic Stroke; Myocardial Infarction; Stroke; Thromboembolism	상세
Cenvacibart	REGN7508	Phase 3 Clinical	Regeneron Pharmaceuticals Inc	Atrial Fibrillation; Peripheral Arterial Disease; Thrombosis; Venous Thromboembolism	상세
Milvexian	BMS-986177; JNJ-70033093; JNJ-3093	Phase 3 Clinical	Bristol-Myers Squibb Company	Acute Coronary Syndrome; Atrial Fibrillation; Contraception; Coronary Thrombosis; Embolism; Ischemic Attack, Transient; Ischemic Stroke; Kidney Failure, Chronic; Renal Insufficiency; Stroke; Thromboembolism; Thrombosis	상세
SHR-2004	SHR-2004	Phase 3 Clinical	Beijing Suncadia Medicine Co Ltd	Arterial Thromboembolism; Atrial Fibrillation; Dyslipidemias; Thromboembolism; Thrombosis; Venous Thromboembolism; Venous Thrombosis	상세
Amrecibart	REGN-9933	Phase 3 Clinical	Regeneron Pharmaceuticals Inc	Atrial Fibrillation; Peripheral Arterial Disease; Venous Thromboembolism	상세
Abelacimab	MAA-868; NOV-12	Phase 3 Clinical	Novartis Pharma Ag	Atrial Fibrillation; Embolism; Neoplasms; Pulmonary Embolism; Stroke; Thromboembolism; Venous Thromboembolism; Venous Thrombosis	상세
EP-7041	EP-7041; HSK-36273	Phase 2 Clinical	Exithera Pharmaceuticals Inc	Blood Coagulation Disorders; Coronavirus Disease 2019 (COVID-19); Kidney Diseases; Thrombocytopenia; Thromboembolism; Thrombosis	상세
Osocimab	BAY-1213790	Phase 2 Clinical	Bayer AG	Kidney Diseases; Kidney Failure, Chronic; Thromboembolism	상세
IONIS-FXIRX	ISIS-404071; BAY-2306001; ISIS-FXIRX; FXI-ASO; IONIS-FXIRX; ISIS-416858	Phase 2 Clinical	Ionis Pharmaceuticals Inc	Thrombosis; Venous Thromboembolism	상세
MK-2060	MK-2060	Phase 2 Clinical	Merck Sharp & Dohme Corp	Kidney Diseases; Kidney Failure, Chronic; Thromboembolism; Thrombosis	상세
SRSD-107	SRSD-107; SRSD107	Phase 2 Clinical	Sirius Therapeutics Inc	Arterial Thromboembolism; Cardiovascular Diseases; Coronary Artery Disease; Coronary Disease; Peripheral Arterial Disease; Thromboembolism; Thrombosis; Venous Thromboembolism	상세
RBD-4059	RBD-4059; RBD4059; SR059; SR-059	Phase 2 Clinical	Suzhou Ribo Life Science Co Ltd	Coronary Artery Disease; Coronary Disease; Kidney Failure, Chronic; Venous Thrombosis	상세
KN-060	KN-060; KN060	Phase 2 Clinical	Suzhou Alphamab Co Ltd	Essential Hypertension; Hypertension; Kidney Failure, Chronic; Obesity; Overweight; Thromboembolism	상세
Ir-CPI	BIOX-101; Ir-CPI	Phase 2 Clinical	Free University Of Brussels	Cerebral Hemorrhage	상세
Fesomersen	ION-957943; IONIS-FXI-LRx; BAY-2976217	Phase 2 Clinical	Ionis Pharmaceuticals Inc	Nephrosis; Thromboembolism	상세
ONO-7269	ONO-7269	Phase 1 Clinical	Ono Pharmaceutical Co Ltd	Cerebral Infarction	상세
BAY-1831865	AB-012; BAY-1831865	Phase 1 Clinical	Aronora Inc	Thrombosis	상세
A-336	A336; A-336	Phase 1 Clinical	Klus Pharma	Thromboembolism	상세
A-186	A-186	Phase 1 Clinical	Sichuan Kelun Pharmaceutical Co Ltd	Thromboembolism	상세
BMS-262084	BMS-262084	Phase 1 Clinical	Bristol-Myers Squibb Company	Thrombosis	상세
ADX-626	ADX-626	Phase 1 Clinical	ADARx Pharmaceuticals Inc	Thrombosis	상세
SBK-013	SBK013; SBK-013	Phase 1 Clinical	Chengdu Shibeikang Biomedical Technology Co Ltd	Arterial Thromboembolism; Thromboembolism; Venous Thromboembolism	상세
XH-S002	XH-S002; XHS002	Phase 1 Clinical		Ischemic Attack, Transient; Stroke	상세
BMS-986209	BMS-986209	Phase 1 Clinical	Bristol-Myers Squibb Company		상세
NIP-003	NIP003; NIP-003; CRB4101; CRB-4101	Phase 1 Clinical	National Institutes Of Pharmaceutical Research And Development Co Ltd	Thromboembolism; Venous Thromboembolism; Venous Thrombosis	상세
Factor XIa Inhibitor (Bayer)	Factor XIa Inhibitor (Bayer)	Phase 1 Clinical	Bayer AG	Blood Coagulation Disorders	상세
SKB-336	SKB-336	Phase 1 Clinical	Sichuan Kelun-Biotech Biopharmaceutical Co Ltd	Embolism; Thromboembolism	상세
SAL-0104	SAL-0104; SAL0104	Phase 1 Clinical	Suzhou Genemen Biotech Co Ltd	Cardiovascular Diseases; Embolism; Ischemic Attack, Transient; Myocardial Infarction; Stroke; Thrombosis; Venous Thromboembolism; Venous Thrombosis	상세
STP122G	STP-122G; STP122G	Phase 1 Clinical	Sirnaomics Biopharmaceuticals (Suzhou) Co Ltd	Embolism and Thrombosis	상세
SHR2285	SHR-2285	Phase 1 Clinical	Jiangsu Hengrui Medicine Co Ltd	Embolism; Thromboembolism; Thrombosis; Venous Thromboembolism	상세

시판 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	가장 빠른 브랜드 이름	가장 빠른 승인 국가	가장 빠른 적응증	가장 빠른 승인 회사	가장 빠른 승인 날짜	적응증	임상 시험
Factor XI concentrate (factor XI deficiency), CSL Behring		Approved	Csl Behring Llc		Australia	Factor XI Deficiency	Csl Behring Llc	2014-07-01	Factor XI Deficiency	상세
Human coagulation Factor XI (LFB)		Approved	Lfb Biotechnologies Sas	Hemoleven	EU	Factor XI Deficiency	Lfb Biotechnologies Sas	1999-07-01	Factor XI Deficiency	상세