언어 선택

Clusterin

Clusterin 분자 정보

영어 이름	Clusterin	시판 약물 수	0
임상 약물 수	1	표적 별명	Epididymis Secretory Sperm Binding Protein，CLI，Apolipoprotein J，ApoJbeta，Complement cytolysis inhibitor a chain，Testosterone-repressed prostate message 2，Complement cytolysis inhibitor b chain，ApoJalpha，AAG4，Complement cytolysis inhibitor，NA1/NA2，APOJ，CLU，Clusterin，Complement-Associated Protein SP-40，40，Complement Lysis Inhibitor，Sulfated Glycoprotein 2，Ku70-Binding Protein 1，TRPM-2，KUB1，Clusterin (Complement Lysis Inhibitor， SP-40，40， Sulfated Glycoprotein 2， Testosterone-Repressed Prostate Message 2， Apolipoprotein J)，Aging-Associated Gene 4 Protein，Aging-Associated Protein 4，APO-J，SGP-2，SP-40，CLU1，CLU2，SGP2，TRPM2
최고 연구 개발 단계	Phase 2 Clinical

영어 이름	Clusterin
표적 별명	Epididymis Secretory Sperm Binding Protein，CLI，Apolipoprotein J，ApoJbeta，Complement cytolysis inhibitor a chain，Testosterone-repressed prostate message 2，Complement cytolysis inhibitor b chain，ApoJalpha，AAG4，Complement cytolysis inhibitor，NA1/NA2，APOJ，CLU，Clusterin，Complement-Associated Protein SP-40，40，Complement Lysis Inhibitor，Sulfated Glycoprotein 2，Ku70-Binding Protein 1，TRPM-2，KUB1，Clusterin (Complement Lysis Inhibitor， SP-40，40， Sulfated Glycoprotein 2， Testosterone-Repressed Prostate Message 2， Apolipoprotein J)，Aging-Associated Gene 4 Protein，Aging-Associated Protein 4，APO-J，SGP-2，SP-40，CLU1，CLU2，SGP2，TRPM2
시판 약물 수	0
임상 약물 수	1
최고 연구 개발 단계	Phase 2 Clinical

Clusterin 제품 목록

속성
Protein (1)
제품 라이브러리
온라인 (1)
종
Human (1)
태그
His Tag (1)
마커
Unconjugated (1)

제품 번호	종	발현 시스템	제품 설명	단백질 구조	순도	특성
CLU-H5227	Human	HEK293	Human Clusterin / CLUS Protein, His Tag

총 수량1

Clusterin분자 배경

Clusterin (CLU) is also known as dimeric acidic glycoprotein (DAG protein), testosterone repressed prostate message-2 (TRPM-2), sulfated glycoprotein-2 (SGP-2) and complement lysis inhibitor (CLI), is a secreted multifunctional glycoprotein protein which belongs to the clusterin family. Intracellular cleavages of the precursor of clusterin remove the signal peptide and generate comparably sized α and β chains which are secreted as an 80 kDa Nglycosylated disulfidelinked heterodimer. DAG protein is predominantly expressed in adult testis, ovary, adrenal gland, liver, heart, and brain and in many epithelial tissues during embryonic development. Clusterin involve in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Upregulation of clusterin mRNA and protein levels detected in diverse disease states and in in vitro systems have led to suggestions that it functions in membrane lipid recycling, in apoptotic cell death, and as a stress-induced secreted chaperone protein, amongst others.

Clusterin분자 별명

CLU,Clusterin,AAG4,APOJ,CLI,KUB1,SGP-2,SP-40,TRPM2

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
Sotevtamab	AB-sCLU mAB; 16B5; AB-16B5	Phase 2 Clinical	National Research Council Biotechnology Research Institute	Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Neoplasm Metastasis; Solid tumours	상세