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Menu
Home PageAll MoleculesClaudin-6
Claudin-6
Claudin-6 Overview
| English Name | Claudin 6 | Approved Drugs | 0 |
| Drugs in Clinical Trials | 13 | Target Synonym | UNQ757/PRO1488，Claudin-6，CLDN6，Claudin 6，Skullin |
| Highest Development Stage | Phase 2 Clinical | ||
| English Name | Claudin 6 |
| Target Synonym | UNQ757/PRO1488，Claudin-6，CLDN6，Claudin 6，Skullin |
| Approved Drugs | 0 |
| Drugs in Clinical Trials | 13 |
| Highest Development Stage | Phase 2 Clinical |
Claudin-6 Product List
- Product Category
Protein (10)Cell (1)
- Product Status
Launched (11)
- Species
Human (11)
- Tag
His Tag & Strep Tag (2)His Tag & Flag Tag & GFP Tag (2)GFP Tag (1)- (5)Flag Tag & His Tag & Strep Tag (1)
- Conjugate
Unconjugated (5)GFP Fusion (2)- (1)Biotin-labeled (3)
Total: 11
- 1
- 2
Claudin-6 Background
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. Claudin-6, also knows as CLDN6, is a multipass transmembrane protein in the Claudin family. Claudin-6 is expressed by epithelial cells where it participates in tissue development and the maintenance of tight junction integrity. And it is one of the entry cofactors for hepatitis C virus. The methylation of CLDN6 may be involved in esophageal tumorigenesis. The gene of CLDN6 is adjacent to another family member CLDN9 on chromosome 16.
Claudin-6 Synonyms
Claudin-6,CLDN6
Antibody Project Trading Platform
| Project Name | Project Stage | Molecule Type | Molecule Source | Disease Area | Indication |
|---|---|---|---|---|---|
| CLDN6 mAb - 01 | PCC | Monoclonal | Humanized Mouse | Solid Tumor | Ovarian cancer,Lung adenocarcinoma |
Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| QLS-5132 | QLS5132; QLS-5132 | Phase 2 Clinical | Qilu Pharmaceutical Co Ltd | Carcinoma, Non-Small-Cell Lung; Endometrial Neoplasms; Ovarian Neoplasms; Solid tumours; Stomach Neoplasms | Details |
| TORL-1-23 | TORL-1-23 | Phase 2 Clinical | Torl Biotherapeutics LLC | Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Endometrial Neoplasms; Fallopian Tube Diseases; Fallopian Tube Neoplasms; Ovarian Neoplasms; Peritoneal Diseases; Peritoneal Neoplasms; Solid tumours | Details |
| PLB-002 | PLB-002; PLB002 | Phase 1 Clinical | PrimeLink BioTherapeutics | Endometrial Neoplasms; Ovarian Neoplasms; Solid tumours; Testicular Neoplasms | Details |
| BGB-B455 | BGB-B455 | Phase 1 Clinical | BeOne Medicines Ltd | Solid tumours | Details |
| AT03-65 | AT-03-65; AT03-65 | Phase 1 Clinical | Axcynsis Therapeutics Pte Ltd | Solid tumours | Details |
| ARC-101 | ARC101; ARC-101 | Phase 1 Clinical | Third Arc Bio Inc | Endometrial Neoplasms; Lung Neoplasms; Ovarian Neoplasms; Solid tumours | Details |
| CTIM-76 | CTIM-76 | Phase 1 Clinical | Integral Molecular Inc | Endometrial Neoplasms; Neoplasms; Ovarian Neoplasms; Solid tumours; Testicular Neoplasms | Details |
| NBL-028 | NBL028; NBL-028 | Phase 1 Clinical | Novarock Biotherapeutics Ltd, Shanghai Xinshi Biological Medicine Co Ltd | Carcinoma, Non-Small-Cell Lung; Endometrial Neoplasms; Neoplasms; Ovarian Neoplasms; Solid tumours; Stomach Neoplasms; Testicular Neoplasms | Details |
| XmAb-541 | XmAb541; XmAb-541 | Phase 1 Clinical | Xencor Inc | Endometrial Neoplasms; Germinoma; Neoplasms, Germ Cell and Embryonal; Ovarian germ cell tumor; Ovarian Neoplasms | Details |
| SAIL-66 | SAIL66; SAIL-66 | Phase 1 Clinical | Chugai Pharmaceutical Co Ltd | Solid tumours | Details |
| CLDN6-CAR-NK Cell Therapy | Phase 1 Clinical | Second Affiliated Hospital Of Guangzhou Medical University | Endometrial Neoplasms; Ovarian Neoplasms | Details | |
| TJ-C64B | TJ-C64B | Phase 1 Clinical | I-Mab Biopharma Co Ltd | Ovarian Neoplasms; Stomach Neoplasms | Details |
| CLDN6 CAR-T cell therapy (BioNTech) | BNT-211 | Phase 1 Clinical | Biontech Se | Germinoma; Neoplasms, Gonadal Tissue; Solid tumours; Testicular Neoplasms | Details |
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