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Claudin-18.2

Claudin-18.2

Claudin-18.2 분자 정보

Molecule Name
Claudin-18 splice variant 2
분자 별명
Claudin-18.2,CLDN18,Claudin-18
Drug Development Progress
임상 약물 수85
시판 약물 수1
최고 연구 개발 단계Approved
표적 별명
UNQ778/PRO1572，CLDN18，Claudin 18，Surfactant Associated Protein J，Surfactant， Pulmonary Associated Protein J，Surfactant Associated 5，Claudin-18，SFTA5，SFTPJ，Claudin 18.2，CLDN18.2
분자 배경
Claudins (CLDNs) are a family of proteins that form tight junctions and maintain the polarity of epithelial and endothelial cells. CLDN18 is specifically expressed in the stomach and lung. Of the two CLDN18 isoform transcripts produced by alternative splicing, CLDN18.2 is a highly selective gastric lineage marker that determines the gastric phenotype in a neoplastic condition, whereas CLDN18.1 is lung specific. CLDN18.2 is a highly selective gastric lineage antigen expressed exclusively on short-lived differentiated gastric epithelial cells where it has only limited accessibility to antibody drugs.14,15 CLDN18.2 is maintained during the course of malignant transformation and thus frequently displayed on the surface of human gastric cancer cells.

Claudin-18.2 제품 목록

Species
  • Human / Cynomolgus（6）
  • Human（4）
  • Mouse（2）
Tag
  • -（5）
  • His Tag & Strep Tag（4）
  • His Tag & Flag Tag（2）
  • GFP Tag（1）
Host
  • InsectCells（6）
  • HEK293（5）
  • E. coli（1）
Conjugate
  • Unconjugated（7）
  • Biotin-labeled（3）
  • GFP Fusion（1）
  • PE Labeled（1）
Grade
  • RUO（12）
Low Endotoxin
  • No（12）
분자Cat. No.Product Name종Host구조순도Activity규격 및 가격
Claudin-18.2
HOT
CL2-H52P7
Human Claudin-18.2 Full Length Protein (VLP)
Human
HEK293
HPLC
ELISASPRIdentity

$620.00

20ug
Claudin-18.2
HOT
CL2-M5585
Mouse Claudin-18.2 Protein, His,Twin-Strep Tag (Detergent)
Mouse
InsectCells
SDS-PAGE
ELISASPR

$845.00

20ug
Claudin-18.2
HOT
CL2-H5587
Human / Cynomolgus Claudin-18.2 Protein, His,Twin-Strep Tag (Detergent)
Human / Cynomolgus
InsectCells
ELISASPRBLI

$1235.00

20ug
Claudin-18.2
HOTAvitag
CL2-H85D3
Biotinylated Human / Cynomolgus Claudin-18.2 Protein, His,Avitag™&Flag Tag (Detergent)
Human / Cynomolgus
InsectCells
SDS-PAGE
ELISA

$1340.00

20ug
Claudin-18.2
CL2-H51D3
Human Claudin-18.2 Full Length Protein, Flag,His Tag (Detergent)
Human
E. coli
ELISASPR

$496.00

20ug
Claudin-18.2
CL2-H5586
Human / Cynomolgus Claudin-18.2 Protein, His,Twin-Strep Tag (Nanodisc)
Human / Cynomolgus
InsectCells
ELISASPRFlow

$1440.00

20ug
Claudin-18.2
CL2-H5589
Human / Cynomolgus Claudin-18.2 Protein, His,Twin-Strep Tag (Nanodisc-pro)
Human / Cynomolgus
InsectCells
ELISASPRBLIFlow

$750.00

20ug
Claudin-18.2
CL2-H82P3
Biotinylated Human Claudin-18.2 Full Length Protein (VLP)
Human
HEK293
HPLC
ELISASPRIdentity

$620.00

20ug
Claudin-18.2
Avitag
CL2-H85D4
Biotinylated Human / Cynomolgus Claudin-18.2 Protein, His,Avitag™&Flag Tag (Nanodisc)
Human / Cynomolgus
InsectCells
ELISAFlow

$1955.00

20ug
Claudin-18.2
CL2-HF218
Fluorescent Human Claudin-18.2 Full Length Protein (VLP)
Human
HEK293
HPLC
ELISASPRFlowIdentity

$620.00

20ug
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항체 프로젝트 거래 플랫폼

프로젝트 이름프로젝트 단계분자 유형분자 출처질병 영역적응증
CLDN18.2 CAR-T - 01PhaseICARNanobodySolid TumorAdvanced refractory gastrointestinal tumors
CLDN18.2 VHH - 01LeadMonoclonalNanobodySolid TumorGastric Cancer,Pancreatic cancer
프로젝트 이름
CLDN18.2 CAR-T - 01
프로젝트 단계
PhaseI
분자 유형
CAR
분자 출처
Nanobody
질병 영역
Solid Tumor
적응증
Advanced refractory gastrointestinal tumors
프로젝트 이름
CLDN18.2 VHH - 01
프로젝트 단계
Lead
분자 유형
Monoclonal
분자 출처
Nanobody
질병 영역
Solid Tumor
적응증
Gastric Cancer,Pancreatic cancer

라이선싱 협력

프로젝트 이름약물 유형치료 영역적응증단계권리 지역
Claudin18.2×CD8+ T bsAbBispecific antibodyOncology/CancerGastric cancer,Pancreatic cancer,OophoromaINDGlobal
CLDN 18.2 CAR-TCell therapyOncology/CancerGastric Cancer,Pancreatic CancerINDGlobal
Claudin18.2 mAbMonospecific antibodyOncology/CancerGastric cancerPhase IGlobal
프로젝트 이름
Claudin18.2×CD8+ T bsAb
약물 유형
Bispecific antibody
치료 영역
Oncology/Cancer
적응증
Gastric cancer,Pancreatic cancer,Oophoroma
단계
IND
권리 지역
Global
프로젝트 이름
CLDN 18.2 CAR-T
약물 유형
Cell therapy
치료 영역
Oncology/Cancer
적응증
Gastric Cancer,Pancreatic Cancer
단계
IND
권리 지역
Global
프로젝트 이름
Claudin18.2 mAb
약물 유형
Monospecific antibody
치료 영역
Oncology/Cancer
적응증
Gastric cancer
단계
Phase I
권리 지역
Global
Resources

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시판 약물 정보

영어 이름연구 코드연구 개발 단계회사가장 빠른 브랜드 이름가장 빠른 승인 국가가장 빠른 적응증가장 빠른 승인 회사가장 빠른 승인 날짜적응증임상 시험
ZolbetuximabGC-182; iMAB-362; IMAB-362ApprovedGanymedVyloy, VYLOY, 威络益JapanStomach NeoplasmsAstellas Pharma Inc2024-03-26
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