언어 선택

CD79B

CD79B 분자 정보

영어 이름	B-cell antigen receptor complex-associated protein beta chain	시판 약물 수	1
임상 약물 수	9	표적 별명	B-Cell Antigen Receptor Complex-Associated Protein Beta Chain，B29，Immunoglobulin-associated B29 protein，Ig-beta，B-cell-specific glycoprotein B29，CD79B，CD79b Molecule，CD79b Molecule， Immunoglobulin-Associated Beta，IGB，CD79B Antigen (Immunoglobulin-Associated Beta)，CD79b Antigen，AGM6
최고 연구 개발 단계	Approved

영어 이름	B-cell antigen receptor complex-associated protein beta chain
표적 별명	B-Cell Antigen Receptor Complex-Associated Protein Beta Chain，B29，Immunoglobulin-associated B29 protein，Ig-beta，B-cell-specific glycoprotein B29，CD79B，CD79b Molecule，CD79b Molecule， Immunoglobulin-Associated Beta，IGB，CD79B Antigen (Immunoglobulin-Associated Beta)，CD79b Antigen，AGM6
시판 약물 수	1
임상 약물 수	9
최고 연구 개발 단계	Approved

CD79B 제품 목록

속성
Protein (9)Cell (1)
제품 라이브러리
온라인 (10)
종
Human (5)Mouse (3)Cynomolgus (2)
태그
Fc Tag (2)His Tag (4)His Tag & Avi Tag (3)- (1)
마커
Unconjugated (5)Biotin-labeled (3)PE Labeled (1)- (1)

제품 번호	종	발현 시스템	제품 설명
HOT CDB-H5259	Human	HEK293	Human CD79B Protein, Fc Tag, low endotoxin
HOT CDB-H52H3	Human	HEK293	Human CD79B Protein, His Tag, low endotoxin (MALS verified)
HOT CDB-H82E3	Human	HEK293	Biotinylated Human CD79B Protein, His,Avitag™ (MALS verified)
HOT CDB-HP2H6	Human	HEK293	PE-Labeled Human CD79B Protein, His Tag (Site-specific conjugation)
SCCHO-ATP171	Human	CHO	CHO/Human CD79B Stable Cell Line
CDB-M5253	Mouse	HEK293	Mouse CD79B Protein, Fc Tag (MALS verified)
CDB-M52H4	Mouse	HEK293	Mouse CD79B Protein, His Tag, low endotoxin (MALS verified)
CDB-M82E3	Mouse	HEK293	Biotinylated Mouse CD79B Protein, His,Avitag™ (MALS verified)
CDB-C52H3	Cynomolgus	HEK293	Cynomolgus CD79B Protein, His Tag (MALS verified)
CDB-C82E5	Cynomolgus	HEK293	Biotinylated Cynomolgus CD79B Protein, His,Avitag™

총 수량10

CD79B분자 배경

B-cell antigen receptor complex-associated protein beta chain (CD79b) is also known as B-cell-specific glycoprotein B29, Ig-beta,Immunoglobulin-associated B29 protein, B29 and IGB, which is a single-pass type I membrane protein containing one Ig-like V-type ( immunoglobulin-like ) domain and one ITAM domain.CD79b is required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR).CD79b can enhance phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. Defects in CD79b are the cause of agammaglobulinemia type 6 (AGM6) that is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development.

CD79B분자 별명

CD79b,B29,IGB,Ig-beta

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
SHR-A1912	SHR-A1912	Phase 3 Clinical	Shanghai Hengrui Pharmaceutical Co Ltd	Lymphoma; Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse	상세
CD19/79b Bi-specific CAR-T Cell Therapy (Shenzhen Geno-Immune Medical Institute)	bi-4SCAR CD19/79b	Phase 2 Clinical	Shenzhen Geno-Immune Medical Institute	Leukemia, B-Cell; Lymphoma, B-Cell	상세
TolDCB29		Phase 2 Clinical	Umc Utrecht	Arthritis, Rheumatoid	상세
JNJ-95566692	JNJ-95566692	Phase 1 Clinical	Janssen Research & Development Llc	Lymphoma, Non-Hodgkin	상세
LTZ-301	LTZ-301	Phase 1 Clinical	LTZ Therapeutics Inc	Autoimmune Diseases; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin	상세
CD79b-19 CAR T Cells Therapy (Massachusetts General Hospital)		Phase 1 Clinical	Massachusetts General Hospital	Lymphoma, B-Cell; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Primary mediastinal B cell lymphoma	상세
Autologous CD79b-targeting Chimeric Antigen Receptor T-cell Therapy（MD Anderson Cancer Center）	JV-213	Phase 1 Clinical	The University Of Texas MD Anderson Cancer Center	Lymphoma; Lymphoma, B-Cell	상세
NBT-508		Phase 1 Clinical	Newbio Therapeutics Inc	Lymphoma, B-Cell; Lymphoma, Non-Hodgkin	상세
CD79b CAR-T cell therapy (Yake Biotechnology)		Phase 1 Clinical	Shanghai YaKe Biotechnology Co Ltd, Zhejiang University	Leukemia, Biphenotypic, Acute; Lymphoma, Non-Hodgkin; Precursor Cell Lymphoblastic Leukemia-Lymphoma	상세

시판 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	가장 빠른 브랜드 이름	가장 빠른 승인 국가	가장 빠른 적응증	가장 빠른 승인 회사	가장 빠른 승인 날짜	적응증	임상 시험
Polatuzumab vedotin	RO-5541077-000; FCU-2711; DCDS-4501A; RG-7596; RO-5541077	Approved	Genentech Inc, Seagen Inc	Polivy, 优罗华	United States	Lymphoma, Large B-Cell, Diffuse	Genentech Inc	2019-06-10	Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma; Lymphoma, B-Cell; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin	상세