언어 선택

CD3 epsilon

CD3 epsilon 분자 정보

영어 이름	T-cell surface glycoprotein CD3 epsilon chain	시판 약물 수	4
임상 약물 수	7	표적 별명	T-cell surface antigen T3/Leu-4 epsilon chain，CD3-Epsilon
최고 연구 개발 단계	Approved

영어 이름	T-cell surface glycoprotein CD3 epsilon chain
표적 별명	T-cell surface antigen T3/Leu-4 epsilon chain，CD3-Epsilon
시판 약물 수	4
임상 약물 수	7
최고 연구 개발 단계	Approved

CD3 epsilon 제품 목록

속성
Protein (18)Beads (1)
제품 라이브러리
온라인 (19)
종
Human (10)Cynomolgus (5)Mouse (2)Canine (1)Rhesus macaque (1)
태그
His Tag (8)His Tag & Fc Tag (2)Fc Tag (4)His Tag & Avi Tag (1)Mouse IgG Fc Tag (1)- (1)Fc Tag & Avi Tag (2)
마커
Unconjugated (10)Biotin-labeled (5)- (1)HRP Labeled (1)AF488 Labeled (2)

제품 번호	종	발현 시스템	제품 설명
HOT CDE-H5223	Human	HEK293	Human CD3 epsilon Protein, His Tag, low endotoxin (MALS verified)
HOT CDE-H8224	Human	HEK293	Biotinylated Human CD3 epsilon Protein, His Tag, ultra sensitivity (primary amine labeling) (MALS verified)
HOT CDE-H82E1	Human	HEK293	Biotinylated Human CD3 epsilon Protein, His,Avitag™
HOT CDN-H5253	Human	HEK293	Human CD3 epsilon Protein, Mouse IgG2a Fc Tag, low endotoxin (MALS verified)
CDE-H5253	Human	HEK293	Human CD3 epsilon (23-48) Protein, Fc Tag, low endotoxin (MALS verified)
CDE-H5256	Human	HEK293	Human CD3 epsilon Protein, Fc,His Tag, low endotoxin (MALS verified)
CDE-H82F3	Human	HEK293	Biotinylated Human CD3 epsilon (23-48) Protein, Fc,Avitag™ (MALS verified)
CDE-HA2H3	Human	HEK293	Alexa Fluor™ 488-Labeled Human CD3 epsilon Protein, His Tag
CDE-HR2H4	Human	HEK293	HRP-Human CD3 epsilon Protein, His Tag
MBS-K026	Human	-	Human CD3E-coupled Magnetic Beads

총 수량19

CD3 epsilon분자 배경

CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.

CD3 epsilon분자 별명

FLJ18683,T3E,TCRE,CD3E,CD3-epsilon

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
Foralumab	NI-0401/α-CD3; TZLS-401; NI-0401	Phase 2 Clinical	Medarex Inc, Novimmune Sa	Alzheimer Disease; Amyotrophic Lateral Sclerosis; Cognitive Dysfunction; Coronavirus Disease 2019 (COVID-19); Crohn Disease; Dementia; Diabetes Mellitus, Type 2; Lower Respiratory Tract Infections; Metabolic Dysfunction-Associated Steatotic Liver Disease; Multiple Sclerosis; Multiple Sclerosis, Chronic Progressive; Multiple System Atrophy; Rejection of renal transplantation	상세
Obrindatamab	MGD-009; B7-H3 x CD3	Phase 2 Clinical	Macrogenics Inc	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Colonic Neoplasms; Melanoma; Mesothelioma; Neuroblastoma; Neurofibrosarcoma; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Rhabdomyosarcoma; Sarcoma; Sarcoma, Synovial; Squamous Cell Carcinoma of Head and Neck; Thyroid Neoplasms; Urinary Bladder Neoplasms; Wilms Tumor	상세
SOA-101	SOA-101; SOA101	Phase 2 Clinical	Shine-On BioMedical Co Ltd	Brain Neoplasms; Breast Neoplasms; Lung Neoplasms; Mouth Neoplasms; Ovarian Neoplasms; Solid tumours	상세
Emerfetamab	AMG-673; AMG673	Phase 1 Clinical	Amgen Inc	Leukemia, Myeloid, Acute	상세
Gresonitamab	AMG-910	Phase 1 Clinical	Amgen Inc	Adenocarcinoma; Esophageal Neoplasms; Stomach Neoplasms	상세
Eluvixtamab	AMG-330; MT-114	Phase 1 Clinical	Amgen Inc	Leukemia, Myeloid, Acute; Myelodysplastic Syndromes	상세
Linclatamig	BLYG-8824; BLYG-8824A; RG 6286	Phase 1 Clinical	Genentech Inc	Colorectal Neoplasms	상세

시판 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	가장 빠른 브랜드 이름	가장 빠른 승인 국가	가장 빠른 적응증	가장 빠른 승인 회사	가장 빠른 승인 날짜	적응증	임상 시험
Tarlatamab	AMG-757	Approved	Amgen Inc	Imdelltra	United States	Small Cell Lung Carcinoma	Amgen Inc	2024-05-16	Astrocytoma; Brain metastases; Carcinoma, Merkel Cell; Carcinoma, Neuroendocrine; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Ganglioglioma; Glioblastoma; Medullary thyroid cancer (MTC); Melanoma; Neoplasms; Neuroendocrine Tumors; Oligodendroglioma; Paranasal Sinus Diseases; Prostatic Neoplasms; Small Cell Lung Carcinoma; Testicular Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms	상세
Elranatamab	PF‑3135; RN-613; PF-06863135	Approved	Pfizer Inc	Elrexfio, ELREXFIO™, ELREXFIO	United States	Multiple Myeloma	Pfizer Inc	2023-08-14	Anemia, Hemolytic, Autoimmune; Bone Marrow Neoplasms; Immunoglobulin Light-chain Amyloidosis; Multiple Myeloma; Smoldering Multiple Myeloma; Spinal Cord Diseases	상세
Glofitamab	RG-6026; RO-7082859; RG6026-2; RO6026	Approved	F. Hoffmann-La Roche Ltd	COLUMVI, 高罗华	Canada	Lymphoma, Large B-Cell, Diffuse	F. Hoffmann-La Roche Ltd	2023-03-25	Central Nervous System Lymphoma; Lymphoma; Lymphoma, B-Cell; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin	상세
Talquetamab	JNJ-7564; JNJ-64407564	Approved	Genmab A/S, Johnson & Johnson Innovative Medicine	TALVEY, 拓立珂	United States	Multiple Myeloma	Janssen Biotech Inc	2023-08-09	Hematologic Neoplasms; Multiple Myeloma	상세