언어 선택

CD27 Ligand

CD27 Ligand 분자 정보

영어 이름	CD70 antigen	시판 약물 수	0
임상 약물 수	37	표적 별명	CD70 antigen，Surface Antigen CD70，LPFS3，CD27L，Tumor necrosis factor ligand superfamily member 7，CD27LG，CD27-L，CD70，CD70 Molecule，TNFSF7，Tumor Necrosis Factor (Ligand) Superfamily， Member 7，Tumor Necrosis Factor Ligand 8A，Ki-24 Antigen，TNLG8A，CD27 Ligand
최고 연구 개발 단계	Phase 2 Clinical

영어 이름	CD70 antigen
표적 별명	CD70 antigen，Surface Antigen CD70，LPFS3，CD27L，Tumor necrosis factor ligand superfamily member 7，CD27LG，CD27-L，CD70，CD70 Molecule，TNFSF7，Tumor Necrosis Factor (Ligand) Superfamily， Member 7，Tumor Necrosis Factor Ligand 8A，Ki-24 Antigen，TNLG8A，CD27 Ligand
시판 약물 수	0
임상 약물 수	37
최고 연구 개발 단계	Phase 2 Clinical

CD27 Ligand 제품 목록

속성
Protein (14)
제품 라이브러리
온라인 (14)
종
Mouse (3)Human (11)
태그
Mouse IgG Fc Tag (2)His Tag (6)His Tag & Avi Tag (1)Fc Tag (1)His Tag & Flag Tag (2)His Tag & Avi Tag & Flag Tag (1)Llama IgG Fc Tag (1)
마커
Unconjugated (6)Biotin-labeled (2)FITC Labeled (2)APC Labeled (1)PE Labeled (1)AF647 Labeled (1)AF488 Labeled (1)

제품 번호	종	발현 시스템	제품 설명
HOT CDD-HF2D4	Human	HEK293	FITC-Labeled Human CD27 Ligand / CD70 Protein, His,Flag Tag, active trimer (MALS verified)
HOT CDL-H5266	Human	HEK293	Human CD27 Ligand / CD70 Protein, Fc Tag, active trimer (MALS verified)
HOT CDL-H52Da	Human	HEK293	Human CD27 Ligand / CD70 Protein, His,Flag Tag, active trimer (MALS verified)
HOT CDL-H82D7	Human	HEK293	Biotinylated Human CD27 Ligand / CD70 Protein, His,Avitag™,Flag Tag, active trimer (MALS verified)
CDL-H5255	Human	HEK293	Human CD27 Ligand / CD70 Protein, Llama IgG2b Fc Tag, low endotoxin
CDL-H525a	Human	HEK293	Human CD27 Ligand / CD70 Protein, Mouse IgG2a Fc Tag, low endotoxin
CDL-HA246	Human	HEK293	Alexa Fluor™ 647-Labeled Human CD27 Ligand / CD70 Protein, His TagStar Staining
CDL-HA247	Human	HEK293	Alexa Fluor™ 488-Labeled Human CD27 Ligand / CD70 Protein, His TagStar Staining
CDL-HA248	Human	HEK293	APC-Labeled Human CD27 Ligand / CD70 Protein, His TagStar Staining
CDL-HF249	Human	HEK293	FITC-Labeled Human CD27 Ligand / CD70 Protein, His TagStar Staining

총 수량14

CD27 Ligand분자 배경

Cluster of Differentiation 70 (CD70) is also known as CD27 ligand (CD27L / CD27LG), TNFSF7, TNFSF7G, is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and is a surface antigen found on activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its receptor CD27 induces in priming, effector functions, differentiation and memory formation of T-cells, and thus is invloved in the biological processes including T-cell activation, the proliferation of costimulated T-cells, as well as the generation of cytolytic T-cells. CD70 on T cells provides costimulatory signals that are required for T cell proliferation, clonal expansion and the promotion of effector T cell formation. CD70 on mouse B cell has been shown to inhibit terminal differentiation of activated B cells into plasma cells and enhances commitment to memory B cell responses. CD70 induces proliferation and IFNγ production, on NK cells.

CD27 Ligand분자 별명

CD70,CD27LG,TNFSF7,TNFSF7G,CD27L

항체 프로젝트 거래 플랫폼

프로젝트 이름	프로젝트 단계	분자 유형	분자 출처	질병 영역	적응증
CD70 VHH - 01	Lead	Monoclonal	Nanobody	Hematological Malignancy	Non-hodgkin lymphoma

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
Cusatuzumab	ARGX-110; JNJ-4550	Phase 2 Clinical	Argenx Se	Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Myelodysplastic Syndromes; Neoplasms	상세
ARX-305	JNJ-0631; ARX-305; NCB-002	Phase 2 Clinical	Ambrx Inc	Lymphoma; Neoplasms	상세
CD70.CAR NK cell therapy (Bellicum Pharma)		Phase 2 Clinical	Bellicum Pharmaceuticals Inc, The University Of Texas MD Anderson Cancer Center	Hodgkin Disease; Lymphoma, B-Cell	상세
ADI-270	ADI-270	Phase 2 Clinical	Adicet Bio Inc	Carcinoma, Renal Cell	상세
CD70 Targeted CAR-T Cells Therapy(UTC Therapeutics)		Phase 2 Clinical	UTC Therapeutics Inc	Lymphoma; Solid tumours; Urologic Neoplasms	상세
Cord Blood-derived CAR NK Cells Targeting CD19/CD70(Shanghai Tongji Hospital)		Phase 2 Clinical	Shanghai Tongji Hospital	Lymphoma, B-Cell	상세
MP0533	MP0533	Phase 2 Clinical	Molecular Partners Ag	Leukemia, Myeloid, Acute	상세
CTX-131	CTX-131	Phase 2 Clinical	Crispr Therapeutics Ag	Carcinoma, Renal Cell; Esophageal Neoplasms; Leukemia, Myeloid, Acute; Lymphoma, B-Cell; Lymphoma, T-Cell; Mesothelioma; Neoplasms; Pancreatic Neoplasms; Uterine Cervical Neoplasms	상세
GD2/CD70 Bi-specific CAR-T Cell Therapy (Shenzhen Geno-Immune Medical Institute)	bi-4SCAR GD2/CD70	Phase 2 Clinical	Shenzhen Geno-Immune Medical Institute	Neoplasms	상세
CD19/70 Bi-specific CAR-T Cell Therapy (Shenzhen Geno-Immune Medical Institute)		Phase 2 Clinical	Shenzhen Geno-Immune Medical Institute	Leukemia, B-Cell; Lymphoma, B-Cell	상세
PSMA/CD70 Bi-specific CAR-T Cell Therapy (Shenzhen Geno-Immune Medical Institute)	bi-4SCAR PSMA/CD70	Phase 2 Clinical	Shenzhen Geno-Immune Medical Institute	Neoplasms	상세
SEA-CD70	SEA-CD70; PF-08046040	Phase 1 Clinical	Seagen Inc	Leukemia, Myeloid, Acute; Myelodysplastic Syndromes	상세
anti-CD70 CAR T-cell therapy linked with modified IL-8 receptor (University of Florida)		Phase 1 Clinical	University Of Florida	Glioblastoma; Glioma; Ovarian Neoplasms; Pancreatic Neoplasms	상세
CAR BCMA-CD70-T cells therapy (The Fifth Medical Center Of Pla General Hospital)		Phase 1 Clinical	The Fifth Medical Center Of Pla General Hospital (Formerly 307 Hospital)	Neoplasms, Plasma Cell	상세
Novel CAR-ITNK Cells Targeting CD70 and CLL1 therapy (Tongji Hospital)		Phase 1 Clinical	Tongji Hospital	Leukemia, Myeloid, Acute	상세
TGFBR-2 KO CD70 CAR NK cell therapy (The University Of Texas MD Anderson Cancer Center)		Phase 1 Clinical	The University Of Texas MD Anderson Cancer Center	Adenocarcinoma, Clear Cell	상세
GEN1160	GEN-1160; GEN1160	Phase 1 Clinical	Genmab A/S	Carcinoma, Renal Cell; Lymphoma, Non-Hodgkin; Nasopharyngeal Carcinoma	상세
CD70-CAR-NK Cell Therapy(Second Affiliated Hospital School Of Zhejiang University School Of Medicine)		Phase 1 Clinical	Second Affiliated Hospital School Of Zhejiang University School Of Medicine	Leukemia, Myeloid, Acute; Lymphoma, T-Cell	상세
Anti-CD70-CAR-T Cell therapy(First Song Biotechnology)		Phase 1 Clinical	Shanghai First Song Therapeutics Co Ltd	Carcinoma, Renal Cell	상세
IB-T101		Phase 1 Clinical	Inceptor Bio LLC	Carcinoma, Renal Cell	상세
Anti-BCMA/CD70 CAR-T cells therapy(The Children'S Hospital, Zhejiang University School Of Medicine)		Phase 1 Clinical	The Children'S Hospital, Zhejiang University School Of Medicine	Lupus Erythematosus, Systemic; Nephrosis	상세
CD70 UCAR T cells Therapy (Nanjing Calmhome Cell and Gene Engineering Institute)	CHT101; CHT-101	Phase 1 Clinical	Nanjing Calmhome Cell and Gene Engineering Institute Co Ltd	Carcinoma, Renal Cell; Glioma; Lupus Erythematosus, Systemic; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell, Cutaneous; Lymphoma, T-Cell, Peripheral; Nasopharyngeal Carcinoma; Neoplasm Metastasis; Ovarian Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Uterine Cervical Neoplasms	상세
Chimeric Antigen Recertor Treatment Targeting CD70(Baylor College of Medicine)		Phase 1 Clinical	Baylor College Of Medicine	Bone Marrow Neoplasms; Kidney Neoplasms; Leukemia, B-Cell; Leukemia, Myeloid, Acute; Leukemia, T-Cell; Lymphoma; Sarcoma; Solid tumours	상세
CAR T-cell Therapy Directed to CD70(St Jude Children's Research Hospital)		Phase 1 Clinical	St. Jude Children'S Research Hospital	Hematologic Neoplasms; Leukemia, Myeloid, Acute; Lymphoma; Myelodysplastic Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma	상세
CD70-targeted CAR-NKT Cells Therapy (CureGenetics)	CGC729; CGC-729	Phase 1 Clinical	Suzhou Cure Genetics Biosciences Co Ltd	Carcinoma, Renal Cell; Solid tumours	상세
ALLO-329	ALLO-329	Phase 1 Clinical	Allogene Therapeutics Inc	Anti-synthetase Syndrome; Dermatomyositis; Lupus Erythematosus, Systemic; Muscular Diseases; Myositis; Scleroderma, Systemic	상세
CD70-CART（Hrain）	HR010; HR-010	Phase 1 Clinical	Hrain Biotechnology Co Ltd	Carcinoma, Renal Cell	상세
Anti-CD19/CD70 NK cell therapy (Zhejiang University)		Phase 1 Clinical	Zhejiang University	Lymphoma, B-Cell	상세
CD70 CAR-T cell therapy (Chongqing Precision Biotech)		Phase 1 Clinical	Chongqing Precision Biotechnology Co Ltd	Arthritis, Juvenile; Carcinoma, Renal Cell; Dermatomyositis; Genital Neoplasms, Female; Lung Neoplasms; Neoplasm Metastasis; Neoplasms; Ovarian Neoplasms; Scleroderma, Systemic; Sjogren's Syndrome; Solid tumours; Thymoma; Thyroid Carcinoma, Anaplastic; Uterine Cervical Neoplasms	상세
IMM-40H	IMM-40H; IMM40H	Phase 1 Clinical		Hematologic Neoplasms; Neoplasms; Solid tumours	상세
ALLO-316	ALLO-316	Phase 1 Clinical	Cellectis Sa, Overland Pharmaceuticals (Shanghai) Co Ltd	Carcinoma, Renal Cell; Leukemia, Myeloid, Acute	상세
CD70 CAR T-cell therapy (Yake Biotechnology)		Phase 1 Clinical	Zhejiang University	Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Multiple Myeloma	상세
C-4-29		Phase 1 Clinical	Chongqing Precision Biotechnology Co Ltd	Carcinoma, Renal Cell; Lupus Erythematosus, Systemic; Multiple Myeloma	상세
[68Ga]Ga-NOTA-RCCB6		Clinical	Huashan Hospital	Kidney Neoplasms; Lymphoma	상세
[18F]RCCB6		Clinical	Huashan Hospital	Kidney Neoplasms	상세
CGC-738	CGC-738; CGC738	Clinical	Suzhou Cure Genetics Biosciences Co Ltd	Carcinoma, Renal Cell	상세
CD19/CD70 CAR-NK cells therapy (Rongu Biotechnology)	RG-1970	Clinical	Hangzhou Rongu Biotechnology Co Ltd	Lymphoma, B-Cell; Neoplasms	상세