CCL19

CCL19

CCL19 분자 정보

Molecule Name
C-C motif chemokine 19
분자 별명
CCL19,MIP-3 beta,MIP-3-beta,ELC,MIP3B,SCYA19,EBI1 ligand chemokine
Drug Development Progress
임상 약물 수1
시판 약물 수0
최고 연구 개발 단계Phase 1 Clinical
표적 별명
Beta-chemokine exodus-3,CK beta-11,Epstein-Barr virus-induced molecule 1 ligand chemokine,EBI1 ligand chemokine,ELC,Macrophage inflammatory protein 3 beta,MIP-3-beta,Small-inducible cytokine A19,MIP3B,SCYA19
분자 배경
C-C motif chemokine 19(CCL19) is as known as CK beta-11, ELC, MIP3B and SCYA19. May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.

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임상 약물 정보

영어 이름연구 코드연구 개발 단계회사적응증임상 시험
Anti-GPC3 chimeric antigen receptor T cell therapy (Hunan Zhaotai Yongren Biotech/Guangdong Zhaotai Invivo Biomedicine)Phase 1 ClinicalGuangdong Zhaotai Invivo Biomedicine Co Ltd, Hunan Zhaotai Yongren Biotech Co Ltd
Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung
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