언어 선택

CBLB

CBLB 분자 정보

영어 이름	E3 ubiquitin-protein ligase CBL-B	시판 약물 수	0
임상 약물 수	3	표적 별명	Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence B，Casitas B-lineage lymphoma proto-oncogene b，RING-type E3 ubiquitin transferase CBL-B，SH3-binding protein CBL-B，RING finger protein 56，Nbla00127，RNF56，Signal transduction protein CBL-B，Cas-Br-M (Murine) Ectropic Retroviral Transforming Sequence B，Cbl Proto-Oncogene， E3 Ubiquitin Protein Ligase B，Cbl Proto-Oncogene B，Cbl Proto-Oncogene B， E3 Ubiquitin Protein Ligase，Cbl-B
최고 연구 개발 단계	Phase 2 Clinical

영어 이름	E3 ubiquitin-protein ligase CBL-B
표적 별명	Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence B，Casitas B-lineage lymphoma proto-oncogene b，RING-type E3 ubiquitin transferase CBL-B，SH3-binding protein CBL-B，RING finger protein 56，Nbla00127，RNF56，Signal transduction protein CBL-B，Cas-Br-M (Murine) Ectropic Retroviral Transforming Sequence B，Cbl Proto-Oncogene， E3 Ubiquitin Protein Ligase B，Cbl Proto-Oncogene B，Cbl Proto-Oncogene B， E3 Ubiquitin Protein Ligase，Cbl-B
시판 약물 수	0
임상 약물 수	3
최고 연구 개발 단계	Phase 2 Clinical

CBLB 제품 목록

속성
Protein (1)
제품 라이브러리
온라인 (1)
종
Human (1)
태그
His Tag (1)
마커
Unconjugated (1)

제품 번호	종	발현 시스템	제품 설명	단백질 구조	순도	특성
CBB-H5148	Human	E. coli	Human CBLB / RNF56 Protein, His Tag

총 수량1

CBLB분자 배경

Casitas B-lineage lymphoma proto-oncogene b (CBLB) is also known as RNF56. E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. Expressed in placenta, heart, lung, kidney, spleen, ovary and testis, as well as fetal brain and liver and hematopoietic cell lines, but not in adult brain, liver, pancreas, salivary gland, or skeletal muscle.

CBLB분자 별명

CBL-B,CBLB,RNF56

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
HST-1011	HST-1011; HST1011	Phase 2 Clinical	HotSpot Therapeutics Inc	Neoplasms; Solid tumours	상세
APN-401	APN-401	Phase 1 Clinical	Apeiron Biologics	Brain metastases; Carcinoma, Renal Cell; Colorectal Neoplasms; Melanoma; Neoplasm Metastasis; Pancreatic Neoplasms; Solid tumours	상세
NX-1607	NX-1607	Phase 1 Clinical	Nurix Therapeutics Inc	Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Transitional Cell; Colorectal Neoplasms; Esophageal Neoplasms; Lymphoma, Large B-Cell, Diffuse; Mesothelioma; Neoplasms; Prostatic Neoplasms, Castration-Resistant; Richter's Syndrome; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Triple Negative Breast Neoplasms; Uterine Cervical Neoplasms	상세