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Catenin beta-1

Catenin beta-1 Overview

English Name	Catenin beta 1	Approved Drugs	1
Drugs in Clinical Trials	10	Target Synonym	NEDSDV，OK/SW-cl.35，CTNNB1，PRO2286，Catenin Beta 1，Catenin (Cadherin-Associated Protein)， Beta 1， 88kDa，CTNNB，Catenin (Cadherin-Associated Protein)， Beta 1 (88kD)，Catenin (Cadherin-Associated Protein)， Beta 1，Catenin Beta-1，Beta-Catenin，Armadillo，MRD19，EVR7，beta Catenin，β-Catenin
Highest Development Stage	Approved

English Name	Catenin beta 1
Target Synonym	NEDSDV，OK/SW-cl.35，CTNNB1，PRO2286，Catenin Beta 1，Catenin (Cadherin-Associated Protein)， Beta 1， 88kDa，CTNNB，Catenin (Cadherin-Associated Protein)， Beta 1 (88kD)，Catenin (Cadherin-Associated Protein)， Beta 1，Catenin Beta-1，Beta-Catenin，Armadillo，MRD19，EVR7，beta Catenin，β-Catenin
Approved Drugs	1
Drugs in Clinical Trials	10
Highest Development Stage	Approved

Catenin beta-1 Product List

Product Category
Protein (2)
Product Status
Launched (2)
Species
Human (2)
Tag
His Tag (1)His Tag & Avi Tag (1)
Conjugate
Unconjugated (1)Biotin-labeled (1)

Cat. No.	Species	Host	Product Description	Structure	Purity	Feature
CA1-H51H3	Human	E. coli	Human Catenin beta-1 Protein, His Tag (MALS verified)
CA1-H81E3	Human	E. coli	Biotinylated Human Catenin beta-1 Protein, His,Avitag™ (MALS verified)

Total: 2

Catenin beta-1 Background

Wnt/β-catenin signaling has been broadly implicated in human cancers and experimental cancer models of animals. The nuclear accumulation of β-catenin has been shown to be positively correlated with poor clinical outcomes, such as cancer progression, invasion, metastasis, and recurrence, resulting in low survival rates.

Catenin beta-1 Synonyms

CTNNB, EVR7, MRD19, NEDSDV, armadillo

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
CEQ-508	CEQ-508	Phase 2 Clinical	Marina Biotech	Adenomatous Polyposis Coli	Details
Foscenvivint	PRI-724; ICG-001; OP-724	Phase 2 Clinical	Prism Pharma Co Ltd, University Of Southern California	Colorectal Neoplasms; Hepatitis B; Hepatitis C; Leukemia, Myelogenous, Chronic; Leukemia, Myeloid, Acute; Liver Cirrhosis; Liver Cirrhosis, Biliary; Pancreatic Neoplasms; Solid tumours	Details
Tegatrabetan	BC-2059; APL-121	Phase 2 Clinical	Allergan Plc	Adenomatous Polyps; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Pancreatic Ductal; Colorectal Neoplasms; Endometrial Neoplasms; Fibroma; Fibromatosis, Aggressive; Hepatoblastoma; Leukemia; Lung Neoplasms; Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Melanoma; Neoplasms; Neuroblastoma; Osteosarcoma; Pancreatic Neoplasms; Sarcoma, Ewing; Solid tumours; Wilms Tumor	Details
Zolucatetide		Phase 2 Clinical	Parabilis Medicines Inc	Adenomatous Polyps	Details
Urbagen gene addition therapy (CTNNB1 Foundation)		Phase 2 Clinical	CTNNB1 Foundation	Neurodevelopmental Disorders	Details
Zolucatetide	FOG-001	Phase 2 Clinical	Parabilis Medicines Inc	Adenomatous Polyposis Coli; Carcinoma, Hepatocellular; Colorectal Neoplasms; Craniopharyngioma; Endometrial Neoplasms; Fibromatosis, Aggressive; Microsatellite instability-high cancer; Neoplasm Metastasis; Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Solid tumours	Details
E-7386	E-7386	Phase 2 Clinical	Eisai Co Ltd, Prism Pharma Co Ltd	Carcinoma, Hepatocellular; Colorectal Neoplasms; Endometrial Neoplasms; Gastrointestinal Neoplasms; Liver Neoplasms; Melanoma; Neoplasms; Solid tumours	Details
DPTX-3186	DPTX-3186; DPTX3186	Phase 1 Clinical	Dewpoint Therapeutics Inc	Solid tumours	Details
ALN-BCAT	ALN-BCAT	Phase 1 Clinical	Alnylam Pharmaceuticals Inc	Carcinoma, Hepatocellular	Details
ST-316	ST-316	Phase 1 Clinical	Sapience Therapeutics Inc	Colonic Neoplasms; Hematologic Neoplasms; Solid tumours	Details

Marketed Drug Information

English Name	Research Code	Highest Development Stage	Company	Earliest Brand Name	Earliest Approval Country	Earliest Indication	Earliest Approval Company	Earliest Approval Date	Indication	Clinical Trial
Tetrandrine	NSC-77037; ES-3000; FF-0019	Approved	Escend Pharmaceuticals Inc		Mainland China	Silicosis; Lung Neoplasms	null	2015-05-19	Leukemia; Leukemia, Myeloid, Acute; Lung Neoplasms; Myelodysplastic Syndromes; Silicosis	Details

Product Reviews

S***e2026-06-23
0People Like
Biotinylated Human Catenin beta-1 Protein, His,Avitag™ (MALS verified)
It is working very well, but the packaging could be optimized a lot more (5 kg of dry ice for one tube seems a bit exaggerated).