언어 선택

beta 2-Microglobulin

beta 2-Microglobulin 분자 정보

영어 이름	Beta-2-microglobulin	시판 약물 수	0
임상 약물 수	0	표적 별명	HDCMA22P，CDABP0092，B2M，Beta-2-Microglobulin，Beta Chain Of MHC Class I Molecules，Beta-2-Microglobin，IMD43，beta 2-Microglobulin
최고 연구 개발 단계	Preclinical

영어 이름	Beta-2-microglobulin
표적 별명	HDCMA22P，CDABP0092，B2M，Beta-2-Microglobulin，Beta Chain Of MHC Class I Molecules，Beta-2-Microglobin，IMD43，beta 2-Microglobulin
시판 약물 수	0
임상 약물 수	0
최고 연구 개발 단계	Preclinical

beta 2-Microglobulin 제품 목록

속성
Protein (3)
제품 라이브러리
온라인 (3)
종
Human (2)Cynomolgus / Rhesus macaque (1)
태그
His Tag (2)Avi Tag (1)
마커
Unconjugated (2)Biotin-labeled (1)

제품 번호	종	발현 시스템	제품 설명
B2M-H5225	Human	HEK293	Human beta 2-Microglobulin / B2M Protein, His Tag, low endotoxin
B2M-H8213	Human	HEK293	Biotinylated Human beta 2-Microglobulin / B2M Protein, Avitag™, low endotoxin (HPLC verified)
B2M-C5226	Cynomolgus / Rhesus macaque	HEK293	Cynomolgus / Rhesus macaque beta 2-Microglobulin / B2M Protein, His Tag

총 수량3

beta 2-Microglobulin분자 배경

β2 microglobulin is also known as Beta-2-microglobulin (B2M), is a component of MHC class I molecules which belongs to the beta-2-microglobulin family. B2M is present on all nucleated cells (excludes red blood cells). B2M associates not only with the alpha chain of MHC class I molecules, but also with class I-like molecules such as CD1 and Qa. An additional function of B2M is association with the HFE protein, together regulating the expression of hepcidin in the liver which targets the iron transporter ferroportin on the cytoplasmic membrane of enterocytes and macrophages for degradation resulting in decreased iron uptake from food and iron release from recycled red blood cells respectively. Loss of this function causes iron excess and hemochromatosis. Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP).

beta 2-Microglobulin분자 별명

B2M

제품 리뷰

K***y2024-10-09
1사람들이 좋아합니다
Human beta 2-Microglobulin / B2M Protein, His Tag, low endotoxin
The product was used to develop and benchmark in-solution binding kinetics of B-2-microglobulin with anti-B-2-microglobulin mAb. We received the product in lyophilized form with clear reconstitution instructions. It is appreciated that the product comes with detailed CoA listing all specific details needed like molecular weight, SDSPAGE data and buffer composition with clear information on additive components. This helped us properly label the protein and perform subsequent binding analysis using Flow Induced Dispersion Analysis (FIDA) for determination of in-solution binding kinetics (kon & koff) parameters.