언어 선택

BAFFR

BAFFR 분자 정보

영어 이름	B-cell activating factor receptor	시판 약물 수	0
임상 약물 수	14	표적 별명	BAFFR，B Cell-Activating Factor Receptor，Prolixin，BROMIX，CD268，Tumor Necrosis Factor Receptor Superfamily， Member 13C，Tumor Necrosis Factor Receptor Superfamily Member 13C，BR3，CVID4，CD268 Antigen，BAFF Receptor，B-Cell Activation Factor Receptor，BAFF-R，TNF Receptor Superfamily Member 13C，BLyS Receptor 3，B-Cell-Activating Factor Receptor，TNFRSF13C
최고 연구 개발 단계	NDA/BLA

영어 이름	B-cell activating factor receptor
표적 별명	BAFFR，B Cell-Activating Factor Receptor，Prolixin，BROMIX，CD268，Tumor Necrosis Factor Receptor Superfamily， Member 13C，Tumor Necrosis Factor Receptor Superfamily Member 13C，BR3，CVID4，CD268 Antigen，BAFF Receptor，B-Cell Activation Factor Receptor，BAFF-R，TNF Receptor Superfamily Member 13C，BLyS Receptor 3，B-Cell-Activating Factor Receptor，TNFRSF13C
시판 약물 수	0
임상 약물 수	14
최고 연구 개발 단계	NDA/BLA

BAFFR 제품 목록

속성
Protein (12)
제품 라이브러리
온라인 (12)
종
Mouse (3)Human (6)Cynomolgus (2)Rat (1)
태그
Fc Tag & Avi Tag (2)Fc Tag (3)Llama IgG Fc Tag (1)His Tag (5)His Tag & Avi Tag (1)
마커
Biotin-labeled (3)Unconjugated (8)PE Labeled (1)

제품 번호	종	발현 시스템	제품 설명
HOT BAR-H52H3	Human	HEK293	Human BAFFR / TNFRSF13C Protein, His Tag, low endotoxin (MALS verified)
HOT BAR-C52H4	Cynomolgus	HEK293	Cynomolgus BAFFR / TNFRSF13C Protein, His Tag (MALS verified)
BAR-H5253	Human	HEK293	Human BAFFR / TNFRSF13C Protein, Fc Tag (MALS verified)
BAR-H5258	Human	HEK293	Human BAFFR / TNFRSF13C Protein, Llama IgG2b Fc Tag, low endotoxin
BAR-H82E4	Human	HEK293	Biotinylated Human BAFFR / TNFRSF13C Protein, His,Avitag™
BAR-H82F3	Human	HEK293	Biotinylated Human BAFFR / TNFRSF13C Protein, Fc,Avitag™ (MALS verified)
BAR-HP2H6	Human	HEK293	PE-Labeled Human BAFFR / TNFRSF13C Protein, His Tag (Site-specific conjugation)
BAR-M5259	Mouse	HEK293	Mouse BAFFR / TNFRSF13C Protein, Fc Tag (MALS verified)
BAR-M52H8	Mouse	HEK293	Mouse BAFFR / TNFRSF13C Protein, His Tag (HPLC verified)
BAR-M82F0	Mouse	HEK293	Biotinylated Mouse BAFFR / TNFRSF13C Protein, Fc,Avitag™ (MALS verified)

총 수량12

BAFFR분자 배경

BAFF receptor (B-cell activating factor receptor, BAFF-R), also known as tumor necrosis factor receptor superfamily member 13C (TNFRSF13C), is a membrane protein of the TNF receptor superfamily which recognizes BAFF. B-cell activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of BAFF in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells.

BAFFR분자 별명

BAFFR,TNFRSF13C,BROMIX,CD268,CVID4,prolixin,BAFF-R

항체 프로젝트 거래 플랫폼

프로젝트 이름	프로젝트 단계	분자 유형	분자 출처	질병 영역	적응증
BAFFR&CD3 BsAb - 01	PCC	Bispecific	Humanized Mouse,Nanobody	Hematological Malignancy,AutoImmunity	Blood tumor,Autoimmune disease

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
Fully Human BAFF-R Chimeric Antigen Receptor T-Cell (Taihe Chunyu)		Phase 2 Clinical	Hebei Tahoe Chunyu Biotechnology Co Ltd	Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Large B-Cell, Diffuse; Waldenstrom Macroglobulinemia	상세
Anti-BAFFR CAR T therapy(The General Hospital Of Tianjin Medical University)	BAFFR CART	Phase 2 Clinical	The General Hospital Of Tianjin Medical University	Myasthenia Gravis; Myositis; Neuromyelitis Optica; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	상세
ESG-206	ESG-206	Phase 2 Clinical	Shanghai Escugen Biotechnology Co Ltd	Lupus Erythematosus, Systemic; Lymphoma, B-Cell; Neoplasms; Purpura, Thrombocytopenic, Idiopathic; Sjogren's Syndrome	상세
dual anti-CD19/anti-BAFF CAR T-cell therapy (Shanghai YaKe Biotechnology/Zhejiang University)		Phase 1 Clinical	Shanghai Yake Biotechnology Co Ltd	Autoimmune Diseases; Dermatomyositis; Lupus Erythematosus, Systemic; Nephritis; Neuromyelitis Optica; Scleroderma, Systemic	상세
SSS-68	SSS68; SSS-68	Phase 1 Clinical	Shenyang Sunshine Pharmaceutical Co Ltd	Glomerulonephritis, IGA	상세
BAFF-R CAR-T cells therapy (Topcel-KH Pharmaceutical)		Phase 1 Clinical	Jiangsu Topcel-KH Pharmaceutical Co Ltd	Lymphoma, B-Cell	상세
BAFFR CAR-T cell therapy (Bio-gene Technology)		Phase 1 Clinical	Guangzhou Bio-Gene Technology Co Ltd	Precursor Cell Lymphoblastic Leukemia-Lymphoma	상세
LY-4152199	LY-4152199; LY4152199	Phase 1 Clinical	Eli Lilly And Company	Lymphoma, B-Cell; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin	상세
B-Cell Activating Factor Receptor (BAFFR)-Based Chimeric Antigen Receptor T-Cells therapy(Mayo Clinic)	MC10029; MC-10029	Phase 1 Clinical	Mayo Clinic	Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Lymphoid; Lymphoma, B-Cell; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell	상세
CD19-BAFF Targeted CAR T-cells Therapy(YaKe Biotechnology)		Phase 1 Clinical	Shanghai YaKe Biotechnology Co Ltd, Zhejiang University	Autoimmune Diseases; Lymphoma, B-Cell; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	상세
KD-6005	KD-6005; KD6005	Phase 1 Clinical	Shanghai Celgen Bio-Pharmaceutical Co Ltd, Shanghai Kanda Bio-Technology Co Ltd	Arthritis, Rheumatoid	상세
Aritinercept	AUR-200; AUR200	Phase 1 Clinical	Thunderbolt Pharma Inc	Autoimmune Diseases	상세
JH-013	JH-013	Phase 1 Clinical	Biotech Pharmaceuticals Co Ltd	Arthritis, Rheumatoid; Hematologic Neoplasms; Lupus Erythematosus, Systemic; Sjogren's Syndrome	상세
BAFFR-CAR T cell therapy (PeproMene Bio)	PMB-101; PMB-CT01	Phase 1 Clinical	City Of Hope National Medical Center, PeproMene Bio Inc	Leukemia, Biphenotypic, Acute; Lymphoma, B-Cell; Lymphoma, Follicular; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	상세