B7-H2 Overview
Molecule Name
ICOS ligand
Synonyms
ICOSLG,B7-H2,B7H2,B7RP-1,B7RP1,CD275,GL50,ICOS-L,ICOSL,LICOS,ICOS ligand
Drug Development Progress
Drugs in Clinical Trials1
Approved Drugs0
Highest Development StagePhase 2 Clinical
Target Synonym
Inducible T-Cell Co-Stimulator Ligand，B7-like protein Gl50，B7-H2，B7RP-1，B7-related protein 1，B7H2，GL50，B7RP1，CD275 Antigen，ICOSL，Inducible T-Cell Costimulator Ligand，B7h，B7 Homologue 2，KIAA0653，Inducible T Cell Costimulator Ligand，Transmembrane Protein B7-H2 ICOS Ligand，ICOS-L，LICOS，B7 homolog 2，CD275，ICOSLG
Background
ICOS ligand (ICOSLG) is also known as B7 homolog 2 (B7-H2), B7-related protein 1 (B7RP-1) and CD antigen CD275, which belongs to the immunoglobulin superfamily and BTN/MOG family. ICOSLG contains one Ig-like C2-type (immunoglobulin-like) domain and one Ig-like V-type (immunoglobulin-like) domain. Isoform 1 is widely expressed, while isoform 2 is detected only in lymph nodes, leukocytes and spleen. B7-H2 is ligand for the T-cell-specific cell surface receptor ICOS. B7-H2 acts as a costimulatory signal for T-cell proliferation and cytokine secretion and induces also B-cell proliferation and differentiation into plasma cells. B7-H2 could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function.
B7-H2 Product List
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1***22020-01-10I purchased this Human B7H2 and only performed one SDS-PAGE. The purity is pretty good and similar to the one on their website.