언어 선택

Axl

Axl 분자 정보

영어 이름	AXL receptor tyrosine kinase	시판 약물 수	2
임상 약물 수	27	표적 별명	EC:2.7.10.1，EC 2.7.10，UFO，AXL Transforming Sequence/Gene，AXL Oncogene，EC 2.7.10.1，JTK11，Tyro7，ARK，Tyrosine-protein kinase receptor UFO，AXL，AXL Receptor Tyrosine Kinase
최고 연구 개발 단계	Approved

영어 이름	AXL receptor tyrosine kinase
표적 별명	EC:2.7.10.1，EC 2.7.10，UFO，AXL Transforming Sequence/Gene，AXL Oncogene，EC 2.7.10.1，JTK11，Tyro7，ARK，Tyrosine-protein kinase receptor UFO，AXL，AXL Receptor Tyrosine Kinase
시판 약물 수	2
임상 약물 수	27
최고 연구 개발 단계	Approved

Axl 제품 목록

속성
Protein (4)
제품 라이브러리
온라인 (4)
종
Human (3)Cynomolgus (1)
태그
His Tag (2)Fc Tag (1)Fc Tag & Avi Tag (1)
마커
Unconjugated (3)Biotin-labeled (1)

제품 번호	종	발현 시스템	제품 설명
HOT AXL-H82F9	Human	HEK293	Biotinylated Human AXL Protein, Fc,Avitag™ (MALS verified)
AXL-H5226	Human	HEK293	Human Axl Protein, His Tag (SPR verified)
AXL-H5253	Human	HEK293	Human Axl Protein, Fc Tag (MALS verified)
AXL-C52H3	Cynomolgus	HEK293	Cynomolgus Axl Protein, His Tag (SPR verified)

총 수량4

Axl분자 배경

AXL Receptor Tyrosine Kinase is also known as Tyrosine-protein kinase receptor UFO, which belongs to the protein kinase superfamily, Tyr protein kinase family and AXL/UFO subfamily. AXL contains two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains and one protein kinase domain. AXL is highly expressed in metastatic colon tumors. AXL is activated by GAS6-binding and subsequent autophosphorylation. AXL is involved in signal transduction from the extracellular matrix into the cytoplasm by binding growth factors, and thus implicated in the stimulation of cell proliferation.

Axl분자 별명

AXL,UFO

라이선싱 협력

프로젝트 이름	약물 유형	치료 영역	적응증	단계	권리 지역
AXL inhibitor	Small molecule	Oncology/Cancer	STK11_mut NSCLC,other cancers	Phase I	Global

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
Batiraxcept	S6-500c; 3D-229; 3D229; 3D-299; Ruga-S6; AB-007; AVB 500; AVB-500; Aravive S-6; AVB-S6-500	Phase 3 Clinical	Aravive Inc	Carcinoma, Ovarian Epithelial; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Fallopian Tube Neoplasms; Glomerulonephritis, IGA; Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Peritoneal Neoplasms; Solid tumours; Uterine Neoplasms	상세
KC1036	KC1036; KC-1036	Phase 3 Clinical	Beijing Konruns Pharmaceutical Co Ltd	Adenocarcinoma; Digestive System Neoplasms; Esophageal Squamous Cell Carcinoma; Hematologic Neoplasms; Neoplasm Metastasis; Sarcoma, Ewing; Solid tumours; Thymus Neoplasms	상세
Sitravatinib	MG-516; MG-91516; MGCD-516; IND-155305; MGCD-0516	Phase 3 Clinical	Mirati Therapeutics Inc	Biliary Tract Neoplasms; Breast Neoplasms; Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Endometrial Neoplasms; Esophageal Squamous Cell Carcinoma; Gastrointestinal Neoplasms; Hepatic Insufficiency; Kidney Neoplasms; Liposarcoma; Lung Diseases; Lung Neoplasms; Metastatic breast cancer; Neoplasms; Oral Squamous Cell Carcinoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms; Ureteral Neoplasms; Uterine Cervical Neoplasms; Uveal melanoma	상세
Butylidenephthalide	NSC-325307; LF-001 (Everfront Biotech); EF-001; HK-001; BDPH	Phase 3 Clinical	Everfront Biotech Co Ltd	Amyotrophic Lateral Sclerosis; Glioblastoma; Glioma	상세
Ningetinib Tosylate	CT-053-PTSA; CT-053	Phase 2 Clinical	Hec Pharm Co Ltd	Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Intestinal Neoplasms; Leukemia, Myeloid, Acute; Lung Neoplasms; Solid tumours; Stomach Neoplasms	상세
Mecbotamab vedotin	BA-3011; BA3011; BA 3011	Phase 2 Clinical	Bioatla	Carcinoma, Non-Small-Cell Lung; Dermatofibrosarcoma; Ovarian Neoplasms; Sarcoma	상세
Merestinib	5OGS5K699E; LY-2801653	Phase 2 Clinical	Eli Lilly And Company	Biliary Tract Neoplasms; Bone metastases; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cholangiocarcinoma; Colorectal Neoplasms; Gallbladder Neoplasms; Leukemia, Myeloid, Acute; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Microsatellite instability-high cancer; Neoplasm Metastasis; Neoplasms; Pancreatic Neoplasms; Skin Melanoma; Solid tumours	상세
Tamnorzatinib	ONO-7475	Phase 2 Clinical	Ono Pharmaceutical Co Ltd	Carcinoma, Non-Small-Cell Lung; Leukemia; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Pancreatic Neoplasms; Solid tumours	상세
Bemcentinib	BGB-324; R-428; BGB-3234	Phase 2 Clinical	Rigel Pharmaceuticals Inc	Adenocarcinoma of Lung; Carcinoma, Non-Small-Cell Lung; CNS Embryonal Tumor; Coronavirus Disease 2019 (COVID-19); Glioblastoma; Inflammatory Breast Neoplasms; Leukemia, Myeloid, Acute; Lung Neoplasms; Melanoma; Mesothelioma; Myelodysplastic Syndromes; Pancreatic Neoplasms; Triple Negative Breast Neoplasms	상세
Enapotamab vedotin	AXL-107-MMAE	Phase 2 Clinical	Genmab A/S, Seagen Inc	Carcinoma, Non-Small-Cell Lung; Endometrial Neoplasms; Melanoma; Ovarian Neoplasms; Sarcoma; Solid tumours; Thyroid Neoplasms; Uterine Cervical Neoplasms	상세
CD73/AXL.HypoSti.CAR-T cells therapy (Pla General Hospital)		Phase 2 Clinical	Pla General Hospital	Solid tumours	상세
FC-084-CSA	FC084CSA; FC-084-CSA	Phase 2 Clinical	FindCure Biosciences (ZhongShan) Co Ltd	Solid tumours	상세
Adrixetinib	Q-702	Phase 2 Clinical	Lead Discovery Center GmbH, Max Planck Institute of Biochemistry, Vichem Chemie	Blastic Plasmacytoid Dendritic Cell Neoplasm; Carcinoma, Hepatocellular; Central Nervous System Lymphoma; Erdheim-Chester Disease; Esophageal Neoplasms; Graft vs Host Disease; Hematologic Neoplasms; Histiocytic Sarcoma; Histiocytosis, Langerhans-Cell; Histiocytosis, Sinus; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Lymphoma; Lymphoma, Follicular; Lymphoma, T-Cell, Cutaneous; Lymphoma, T-Cell, Peripheral; Myelodysplastic Syndromes; Neoplasm Metastasis; Neoplasms; Neoplasms, Plasma Cell; Solid tumours; Stomach Neoplasms; Uterine Cervical Neoplasms; Waldenstrom Macroglobulinemia	상세
Dubermatinib	TP-0903	Phase 1 Clinical	Sumitomo Dainippon	Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Melanoma; Ovarian Neoplasms; Solid tumours	상세
INCB-081776	INCB-81776; INCB-081776	Phase 1 Clinical	Incyte Corp	Solid tumours; Squamous Cell Carcinoma of Head and Neck	상세
BPI-9016	BPI-9016; BPI-9016M	Phase 1 Clinical	Betta Pharmaceuticals Co Ltd	Carcinoma, Non-Small-Cell Lung; Solid tumours	상세
A-416	A416; A-416	Phase 1 Clinical	Klus Pharma Inc	Solid tumours	상세
NTQ-2494	NTQ2494; NTQ-2494	Phase 1 Clinical	Nanjing Zhengda Tianqing Pharmaceutical Co Ltd	Hematologic Neoplasms; Leukemia, Myeloid, Acute; Solid tumours	상세
CTS-2016	CTS-2016	Phase 1 Clinical	CytosinLab Therapeutics Co Ltd	Leukemia, Myeloid, Acute; Myelodysplastic Syndromes	상세
Ligritinib	AB-801	Phase 1 Clinical	Arcus Biosciences Inc	Neoplasms	상세
XZB-0004	XZB-0004; SLC-0211; SLC-391	Phase 1 Clinical	Xuanzhu (Shijiazhuang) Biotechnology Co Ltd	Carcinoma, Non-Small-Cell Lung; Foodborne Diseases; Hematologic Neoplasms; Leukemia, Myeloid, Acute; Lung Neoplasms; Myelodysplastic Syndromes; Solid tumours	상세
NP-107	NP107; NP-107	Phase 1 Clinical	Shanghai Nawei Biotechnology Co Ltd	Solid tumours	상세
TT-00973	TT-00973	Phase 1 Clinical	TransThera Sciences (Nanjing) Inc	Solid tumours	상세
AGX-0073	AGX-0073	Phase 1 Clinical	Shanghai Aojian Biological Technology Co Ltd	Solid tumours	상세
Denfivontinib Hydrochloride	SKI-G-801; G-801; G-749 Hydrochloride	Phase 1 Clinical	Genosco	Leukemia, Myeloid, Acute; Solid tumours	상세
NP-01 (Shijiazhuang No.4 Pharmaceutical/Nanjing Nadingfei Medical Technology)	NP-01	Phase 1 Clinical	Nanjing Nadingfei Pharmaceutical Technology Co Ltd, Shijiazhuang No 4 Pharmaceutical Co Ltd	Liver Neoplasms; Lung Neoplasms; Solid tumours; Stomach Neoplasms	상세
NPS-1034	HOPE-777; KDDF-201111-02		Neopharma Ltd		상세

시판 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	가장 빠른 브랜드 이름	가장 빠른 승인 국가	가장 빠른 적응증	가장 빠른 승인 회사	가장 빠른 승인 날짜	적응증	임상 시험
Gilteritinib Fumarate	ASP-2215 hemifumarate; ASP-2215; 66D-92MGC8M (UNII code)	Approved	Astellas Pharma Inc	Xospata	Japan	Leukemia, Myeloid, Acute	Astellas Pharma Inc	2018-09-21	Carcinoma, Non-Small-Cell Lung; Hepatic Insufficiency; Leukemia, Myeloid, Acute; Lung Neoplasms; Renal Insufficiency; Solid tumours	상세
Cabozantinib S-malate	XL-184; BMS-907351; RO7047650; RO-7047650	Approved	Exelixis Inc	Cometriq, Cabometyx	United States	Thyroid Neoplasms; Carcinoma, Neuroendocrine	Exelixis Inc	2012-11-29	Adenocarcinoma, Clear Cell; Adenocarcinoma, Follicular; Adenoma, Islet Cell; Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Astrocytoma; Bile Duct Neoplasms; Bone metastases; Brain metastases; Brain Neoplasms; Breast Neoplasms; Carcinoma, Adenosquamous; Carcinoma, Endometrioid; Carcinoma, Hepatocellular; Carcinoma, Merkel Cell; Carcinoma, Neuroendocrine; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Papillary; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Central Nervous System Neoplasms; Cholangiocarcinoma; Colorectal Neoplasms; Endometrial Neoplasms; Fallopian Tube Neoplasms; Gastroenteropancreatic neuroendocrine tumor; Glioblastoma; Glioma; Gliosarcoma; Hepatic Insufficiency; Hepatoblastoma; HIV Infections; Kidney Neoplasms; Leiomyosarcoma; Leukemia, Myeloid, Acute; Lymphoma; Medullary thyroid cancer (MTC); Melanoma; Meningioma; Multiple Myeloma; Neoplasm Metastasis; Neoplasms; Neoplasms, Germ Cell and Embryonal; Neuroblastoma; Neuroendocrin	상세