언어 선택

APRIL

APRIL 분자 정보

영어 이름	Tumor necrosis factor ligand superfamily member 13	시판 약물 수	2
임상 약물 수	29	표적 별명	Tumor Necrosis Factor Ligand 7B，CD256 Antigen，TNLG7B，CD256，TNF- and APOL-related leukocyte expressed ligand 2，TNFSF13，TNF-related death ligand 1，ZTNF2，TALL-2，APRIL，Tumor necrosis factor ligand superfamily member 13，TNF Superfamily Member 13，Tumor Necrosis Factor (Ligand) Superfamily， Member 13，TRDL-1，TALL2，Tumor Necrosis Factor Superfamily Member 13，Tumor Necrosis Factor-Like Protein ZTNF2，UNQ383/PRO715，A Proliferation-Inducing Ligand，Tumor Necrosis Factor-Related Death Ligand-1
최고 연구 개발 단계	Approved

영어 이름	Tumor necrosis factor ligand superfamily member 13
표적 별명	Tumor Necrosis Factor Ligand 7B，CD256 Antigen，TNLG7B，CD256，TNF- and APOL-related leukocyte expressed ligand 2，TNFSF13，TNF-related death ligand 1，ZTNF2，TALL-2，APRIL，Tumor necrosis factor ligand superfamily member 13，TNF Superfamily Member 13，Tumor Necrosis Factor (Ligand) Superfamily， Member 13，TRDL-1，TALL2，Tumor Necrosis Factor Superfamily Member 13，Tumor Necrosis Factor-Like Protein ZTNF2，UNQ383/PRO715，A Proliferation-Inducing Ligand，Tumor Necrosis Factor-Related Death Ligand-1
시판 약물 수	2
임상 약물 수	29
최고 연구 개발 단계	Approved

APRIL 제품 목록

속성
Protein (9)Kits (1)
제품 라이브러리
온라인 (10)
종
Human (6)Cynomolgus (2)Mouse (2)
태그
Fc Tag & Avi Tag (1)His Tag & Flag Tag (2)His Tag & Avi Tag (2)Fc Tag (3)- (1)His Tag (1)
마커
Biotin-labeled (3)Unconjugated (6)- (1)

제품 번호	종	발현 시스템	제품 설명
HOT APL-H52D1	Human	HEK293	Human APRIL / TNFSF13 Protein, His,Flag Tag, active trimer, low endotoxin (MALS verified)
HOT APL-H82Q8	Human	HEK293	Biotinylated Human APRIL / TNFSF13 Protein, Avitag™,His Tag, active trimer (MALS verified)
HOT APL-C52D2	Cynomolgus	HEK293	Cynomolgus APRIL / TNFSF13 Protein, His,Flag Tag, active trimer, low endotoxin (MALS verified)
APL-H5263	Human	HEK293	Human APRIL / TNFSF13 Protein, Fc Tag, low endotoxin
APL-H5363	Human	CHO	Human APRIL / TNFSF13 Protein, Fc Tag, low endotoxin (MALS verified)
APL-H82F5	Human	HEK293	Biotinylated Human APRIL / TNFSF13 Protein, Fc,Avitag™
FRT-P035	Human	-	Human APRIL / TACI Inhibitor Screening Kit (TR-FRET)
APL-M5243	Mouse	HEK293	Mouse APRIL / TNFSF13 Protein, His Tag, low endotoxin (MALS verified)
APL-M5363	Mouse	CHO	Mouse APRIL / TNFSF13 Protein, Fc Tag, low endotoxin (MALS verified)
APL-C82Q3	Cynomolgus	HEK293	Biotinylated Cynomolgus APRIL / TNFSF13 Protein, Avitag™,His Tag, low endotoxin (MALS verified)

총 수량10

APRIL분자 배경

APRIL(a proliferation-inducing ligand) is also known as Tumor necrosis factor ligand superfamily member 13, TALL-2, TRDL-1, CD256, TNFSF13, cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. APRIL is a cytokine of the tumor necrosis factor family associated mainly with hematologic malignancies. The closely related TNF family ligands B cell activation factor (BAFF) and a proliferation-inducing ligand (APRIL) serve in the generation and maintenance of mature B-lymphocytes. Both BAFF and APRIL assemble as homotrimers that bind and activate several receptors that they partially share. BAFF-APRIL heteromers of different stoichiometries have distinct receptor-binding properties and activities. In addition, expression of APRIL was regulated by miR-145 in GC cells.

APRIL분자 별명

APRIL,TNFSF13,TALL-2,TRDL-1,CD256,TALL2,ZTNF2

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
Zigakibart	BION-1301; FUB523; FUB-523	Phase 3 Clinical	Aduro Biotech Inc	Glomerulonephritis, IGA; Multiple Myeloma; Proteinuria	상세
Povetacicept	ALPN-303; ALPN 30x	Phase 3 Clinical	Alpine Immune Sciences Inc	Anemia, Hemolytic, Autoimmune; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Cytopenia; Glomerulonephritis; Glomerulonephritis, IGA; Glomerulonephritis, Membranous; Inflammation; Lupus Erythematosus, Systemic; Lupus Nephritis; Myasthenia Gravis; Nephrosis; Purpura, Thrombocytopenic, Idiopathic; Sjogren's Syndrome	상세
CLYM-116	CLYM116; MIL116	Phase 2 Clinical	Beijing Mabworks Biotech Co Ltd	Glomerulonephritis, IGA	상세
IM-21	IM21; IM-21	Phase 1 Clinical	Imunopharm Technology Co Ltd	Multiple Myeloma	상세
anti-BCMA CAR T-cell therapy (Sichuan University)		Phase 1 Clinical	Sichuan University	Multiple Myeloma	상세
dual anti-CS-1/anti-BCMA CAR T-cell therapy (Wuhan Sian Medical Technology)		Phase 1 Clinical	Wuhan Sian Biotechnology Co Ltd	Multiple Myeloma	상세
dual anti-BCMA/anti-CD38 CAR T-cell therapy (Shengyan Pharmaceutical Technology/Tongji Medical College)		Phase 1 Clinical	Tongji Medical College	Multiple Myeloma	상세
BCMA-CS1 cCAR T-cell therapy		Phase 1 Clinical	iCell Gene Therapeutics LLC	Multiple Myeloma	상세
anti-BCMA CAR T-cell therapy (National Cancer Institute)		Phase 1 Clinical	National Cancer Institute	Multiple Myeloma	상세
anti-BCMA CAR T-cell therapy (Kite)	FHVH33-CD8BBZ	Phase 1 Clinical	Teneobio Inc	Multiple Myeloma	상세
anti-BCMA CAR T-cell therapy (Yake Biotechnology/Zhejiang University)		Phase 1 Clinical	Shanghai Yake Biotechnology Co Ltd	Multiple Myeloma	상세
CBG-002	CBG-002	Phase 1 Clinical	Carbiogene Therapeutics Co Ltd	Multiple Myeloma	상세
BCMA-CD19 cCAR		Phase 1 Clinical	iCell Gene Therapeutics LLC	Lupus Erythematosus, Systemic; Lupus Nephritis; Multiple Myeloma; Neuromyelitis Optica; Rejection of organ transplantation; Waldenstrom Macroglobulinemia	상세
SSS-68	SSS68; SSS-68	Phase 1 Clinical	Shenyang Sunshine Pharmaceutical Co Ltd	Glomerulonephritis, IGA	상세
GenSci-136	GenSci136	Phase 1 Clinical	Changchun GeneScience Pharmaceuticals Co Ltd	Autoimmune Diseases; Glomerulonephritis, IGA; Lupus Erythematosus, Systemic; Myasthenia Gravis; Sjogren's Syndrome	상세
JADE-001	JADE-001; JADE001; PR030; PR-030; JADE101; JADE-101	Phase 1 Clinical	Paragon Therapeutics Inc	Glomerulonephritis, IGA	상세
KD-6005	KD-6005; KD6005	Phase 1 Clinical	Shanghai Celgen Bio-Pharmaceutical Co Ltd, Shanghai Kanda Bio-Technology Co Ltd	Arthritis, Rheumatoid	상세
Anti-BCMA CAR T-cell therapy (Actavis/Eugia Pharma)		Phase 1 Clinical	Actavis Inc, Eugia Pharma Specialities Ltd	Multiple Myeloma	상세
anti-TriPRIL CAR T-cell therapy（Massachusetts General Hospital）		Phase 1 Clinical	Massachusetts General Hospital	Multiple Myeloma	상세
Aritinercept	AUR-200; AUR200	Phase 1 Clinical	Thunderbolt Pharma Inc	Autoimmune Diseases	상세
RO-7297089	RO-7297089; AFM-26; RG-6296	Phase 1 Clinical	Genentech Inc	Multiple Myeloma	상세
APRIL CAR-T Cell therapy (Yake Biotechnology)		Phase 1 Clinical	Shanghai YaKe Biotechnology Co Ltd	Multiple Myeloma	상세
Anti-BCMA CAR T-cell therapy (Huazhong University of Science and Technology)		Clinical	Huazhong University Of Science And Technology	Multiple Myeloma	상세
anti-BMCA CAR NK-cell therapy (Hangzhou Cheetah Cell Therapeutics/Zhejiang University)		Clinical	Zhejiang University	Multiple Myeloma	상세
anti-BCMA CAR T-cell therapy engineered to express anti-IL6 scFv and IL1RA (Celledit)		Clinical	Celledit Llc	Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Multiple Myeloma; Precursor Cell Lymphoblastic Leukemia-Lymphoma	상세
anti-BCMA CAR T-cell therapy (Shanghai GeneChem)		Clinical	Shanghai Genechem Co Ltd	Multiple Myeloma	상세
anti-BCMA/NKG2DL/FAP TCR T-cell therapy (Guangdong VitaLife)		Clinical	Guangdong Vitalife Biotechnology Co Ltd	Multiple Myeloma	상세
bispecific anti-CD19/anti-BCMA CAR T-cell therapy (Shanghai Hrain Biotechnology)	HRAIN-002	Clinical	Hrain Biotechnology Co Ltd	Multiple Myeloma	상세
BCMA-UCART	BCMA-UCART	Clinical	BRL Medicine Inc	Multiple Myeloma	상세

시판 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	가장 빠른 브랜드 이름	가장 빠른 승인 국가	가장 빠른 적응증	가장 빠른 승인 회사	가장 빠른 승인 날짜	적응증	임상 시험
Telitacicept	RCT-18; RCT18; RC-18; RC18	Approved		泰爱, Tai’ai	Mainland China	Lupus Erythematosus, Systemic	RemeGen Co Ltd	2021-03-09	Arthritis, Rheumatoid; Eye Diseases; Glomerulonephritis, IGA; Hepatitis, Autoimmune; Immunoglobulin G4-Related Disease; Lung Diseases, Interstitial; Lupus Erythematosus, Systemic; Lupus Nephritis; Multiple Sclerosis; Multiple Sclerosis, Relapsing-Remitting; Myasthenia Gravis; Nephrosis; Neuromyelitis Optica; Sjogren's Syndrome	상세
Sibeprenlimab	VIS-649	Approved	Visterra Inc	Voyxact	United States	Glomerulonephritis, IGA	Otsuka Pharmaceutical Co Ltd	2025-11-25	Glomerulonephritis; Glomerulonephritis, IGA; Sjogren's Syndrome	상세