언어 선택

APP

APP 분자 정보

영어 이름	Beta amyloid A4 protein	시판 약물 수	13
임상 약물 수	52	표적 별명	Beta-CTF，Amyloid Beta Precursor Protein，Cerebral Vascular Amyloid Peptide，Beta-Amyloid Precursor Protein，Amyloid-Beta A4 Protein，Beta-Amyloid Peptide，Alzheimer Disease，CTFgamma，ABETA，AAA，PN2，Amyloid beta-Peptides，Amyloid intracellular domain 57，APP，Amyloid intracellular domain 59，PN-II，Alpha-secretase C-terminal fragment，AICD-50，S-APP-alpha，A4，S-APP-beta，Alzheimer disease amyloid protein，Abeta40，Gamma-CTF(59)，Abeta42，Gamma-CTF(57)，Alpha-CTF，Amyloid intracellular domain 50，AID(59)，Gamma-CTF(50)，AID(57)，Beta-secretase C-terminal fragment，Amyloid-beta precursor protein，Amyloid precursor protein，AD1，AICD-57，Beta-APP42，APPI，Beta-APP40，AID(50)，CVAP，AICD-59，Amyloid Beta (A4) Precursor Protein，Peptidase Nexin-II，Protease Nexin-II，PreA4，ABPP，Testicular Tissue Protein Li 2，Beta-Amyloid Peptide(1-40)，Beta-Amyloid Peptide(1-42)，Amyloid Beta A4 Protein
최고 연구 개발 단계	Approved

영어 이름	Beta amyloid A4 protein
표적 별명	Beta-CTF，Amyloid Beta Precursor Protein，Cerebral Vascular Amyloid Peptide，Beta-Amyloid Precursor Protein，Amyloid-Beta A4 Protein，Beta-Amyloid Peptide，Alzheimer Disease，CTFgamma，ABETA，AAA，PN2，Amyloid beta-Peptides，Amyloid intracellular domain 57，APP，Amyloid intracellular domain 59，PN-II，Alpha-secretase C-terminal fragment，AICD-50，S-APP-alpha，A4，S-APP-beta，Alzheimer disease amyloid protein，Abeta40，Gamma-CTF(59)，Abeta42，Gamma-CTF(57)，Alpha-CTF，Amyloid intracellular domain 50，AID(59)，Gamma-CTF(50)，AID(57)，Beta-secretase C-terminal fragment，Amyloid-beta precursor protein，Amyloid precursor protein，AD1，AICD-57，Beta-APP42，APPI，Beta-APP40，AID(50)，CVAP，AICD-59，Amyloid Beta (A4) Precursor Protein，Peptidase Nexin-II，Protease Nexin-II，PreA4，ABPP，Testicular Tissue Protein Li 2，Beta-Amyloid Peptide(1-40)，Beta-Amyloid Peptide(1-42)，Amyloid Beta A4 Protein
시판 약물 수	13
임상 약물 수	52
최고 연구 개발 단계	Approved

APP 제품 목록

속성
Protein (5)Cell (1)
제품 라이브러리
온라인 (6)
종
Mouse (1)Human (5)
태그
His Tag (5)GFP Tag (1)
마커
Unconjugated (5)- (1)

제품 번호	종	발현 시스템	제품 설명
HOT APP-H52H5	Human	HEK293	Human APP / SAPPbeta Protein, His Tag (MALS verified)
HOT APP-M52H3	Mouse	HEK293	Mouse APP / N-APP Protein, His Tag (MALS verified)
APP-H51H6	Human	E. coli	Human APP / Abeta42 Protein, His Tag
APP-H51H9	Human	E. coli	Human APP / Abeta40 (672-711) Protein, His Tag
APP-H52H3	Human	HEK293	Human APP Protein, His Tag (active enzyme, MALS verified)
CHEK-ATP081	Human	HEK293	HEK293/Human APP (GFP) Stable Cell Line

총 수량6

APP분자 배경

Amyloid precursor protein (APP) is a type I integral membrane protein ubiquitously expressed in many tissues and concentrated in the synapses of neurons. It has three predominant splice variants: APP695, APP751, and APP770. The majority of APP is cleaved at the plasma membrane by the α-secretase in the non-amyloidogenic pathway. The amyloidogenic pathway starts with β-secretase cleavage by BACE1 on the N-terminal part of the Aβ domain, releasing sAPPβ from a membrane-anchored fragment named βCTF or C99, which is subsequently cleaved by γ-secretase to release Aβ.

APP분자 별명

ABPP,APPI,Amyloid-beta A4 protein

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
Buntanetap	ANVS-405; ANVS-401	Phase 3 Clinical	Raptor Pharmaceutical	Alzheimer Disease; Chronic Traumatic Encephalopathy; Cognitive Dysfunction; Down Syndrome; Frontotemporal Dementia; Parkinson Disease	상세
Gantenerumab	MAb-31; R-1450; RG-1450; R-04909832	Phase 3 Clinical	Chugai Pharmaceutical Co Ltd	Alzheimer Disease; Dementia	상세
Valiltramiprosate	BLU-8499; NRM-8499; ALZ-801	Phase 3 Clinical	Alzheon Inc	Alzheimer Disease	상세
Solanezumab	LY-2062430	Phase 3 Clinical	Eli Lilly And Company	Alzheimer Disease; Cognition Disorders; Dementia	상세
Tramiprosate	3-APS; NC-531; NC-758	Phase 3 Clinical	Bellus Health Inc	Alzheimer Disease; Glaucoma; Neurodegenerative Diseases; Stroke	상세
Remternetug	LY-3372993; LY3372993	Phase 3 Clinical	Eli Lilly And Company	Alzheimer Disease; Dementia	상세
[F-18]Flornaptitril	[F-18]FDDNP; F-18-FNT-PET	Phase 3 Clinical	University Of California At Los Angeles	Alzheimer Disease; Chronic Traumatic Encephalopathy	상세
F-18 Florbetazine		Phase 3 Clinical	Hta Co Ltd	Alzheimer Disease	상세
RP-902	RP902; RP-902	Phase 3 Clinical	Risen (Suzhou) Pharma Tech Co Ltd	Alzheimer Disease	상세
Trontinemab	RO-7126209; RG-6102	Phase 3 Clinical	F. Hoffmann-La Roche Ltd	Alzheimer Disease	상세
GAL-101	EG-030; GAL-101; MRZ-99030	Phase 2 Clinical	Tel Aviv University Trust	Geographic Atrophy; Glaucoma	상세
L-clausenamide		Phase 2 Clinical	Fuan Pharmaceutical (Group) Co Ltd, Guangzhou Nuohao Pharmaceutical Technology Co Ltd, Institue Of Materia Medica Chinese Academy Of Medical Science, Qingdao Huanghai Pharmaceutical Co Ltd	Cognitive Dysfunction; Dementia; Memory Disorders	상세
Crenezumab	MABT-5102-A; RG-7412; R-7412; RO-5490245	Phase 2 Clinical	Ac Immune Sa	Alzheimer Disease	상세
(-)-Epigallocatechin gallate	AB-4166	Phase 2 Clinical	Charite Universitaetsmedizin Berlin	Alzheimer Disease; Colonic Neoplasms; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Frailty; Glaucoma, Open-Angle; Huntington Disease; Hypertension; Idiopathic Pulmonary Fibrosis; Inflammation; Insulin Resistance; Leukemia; Liver Cirrhosis; Lung Diseases, Interstitial; Multiple Sclerosis, Relapsing-Remitting; Muscular Dystrophy, Duchenne; Neoplasms; Obesity; Ocular Hypertension; Papillomavirus Infections; Parkinson Disease; Peripheral Nervous System Diseases; Prostatic Neoplasms; Uterine Cervical Diseases	상세
11C-BF-227	11C-BF-227; [11C]BF-227	Phase 2 Clinical	Tohoku University	Diagnostic agents	상세
Pittsburgh Compound B	[11C]PIB; [11C]6-OH-BTA-1; 11C-PIB	Phase 2 Clinical	Ge Healthcare, The University Of Utah, University Of Pittsburgh, Uppsala Universitet	Alcoholism; Alzheimer Disease; Brain Concussion; Breast Neoplasms; Dementia; Ovarian Neoplasms; Parkinson Disease	상세
Zervimesine fumarate	SV-119; CT-1812	Phase 2 Clinical	Cogrx	Alzheimer Disease; Cognition Disorders; Lewy Body Disease; Macular Degeneration	상세
[18F]THK-5105	[18F]THK-5105	Phase 2 Clinical	Tohoku University	Alzheimer Disease	상세
Edonerpic	T-817 MA	Phase 2 Clinical	Fujifilm Group, Toyama Chemical Co Ltd	Alzheimer Disease; Cognitive Dysfunction; Hepatic Insufficiency	상세
ABvac-40	ABvac-40	Phase 2 Clinical	Araclon Biotech Sl	Alzheimer Disease; Cognitive Dysfunction	상세
TML-6	TML-6	Phase 2 Clinical	Merry Life Biomedical Co Ltd	Alzheimer Disease	상세
PHENOGENE-1A		Phase 2 Clinical	PhenoNet Inc	Alzheimer Disease; Amyotrophic Lateral Sclerosis	상세
PK-051	PK051; PK-051	Phase 2 Clinical	PharmaKure Ltd	Alzheimer Disease; Cognitive Dysfunction	상세
PRI-002	RD-2; PRI-002	Phase 2 Clinical	Priavoid, PRInnovation GmbH	Alzheimer Disease; Cognitive Dysfunction	상세
18F-92	18F-92	Phase 2 Clinical	First Affiliated Hospital Of Fujian Medical University	Alzheimer Disease	상세
OAB-14	OAB-14	Phase 2 Clinical	Shenyang Pharmaceutical University	Alzheimer Disease	상세
Mivelsiran	ALN-APP	Phase 2 Clinical	Sirna Therapeutics Inc	Alzheimer Disease; Cerebral Amyloid Angiopathy	상세
SHR-1707	SHR-1707	Phase 2 Clinical	Shanghai Hengrui Pharmaceutical Co Ltd	Alzheimer Disease	상세
BEY-2153	BEY-2153	Phase 2 Clinical	Beyondbio Inc	Alzheimer Disease	상세
Ezeprogind	AZP-2006	Phase 2 Clinical	Alzprotect, Inserm	Alzheimer Disease; Supranuclear Palsy, Progressive	상세
[18F]THK-5117	[18F]THK-5117	Phase 2 Clinical	Tohoku University	Alzheimer Disease	상세
AD-35	AD-35	Phase 2 Clinical	Zhejiang Hisun Pharmaceutical Co Ltd	Alzheimer Disease	상세
APH-1105	APH-1105	Phase 2 Clinical	Aphios Corporation	Alzheimer Disease; Dementia	상세
RIV-1061-IR	RIV-1061; RIV-1061-IR	Phase 1 Clinical	Revivo Therapeutics	Alzheimer Disease; Cognition Disorders	상세
A ß antibody Fab		Phase 1 Clinical	Eli Lilly And Company	Alzheimer Disease	상세
MDR-1339	DBT-1339; MDR-1339	Phase 1 Clinical	Medifron	Alzheimer Disease	상세
chimeric fusion protein (Attralus/University of Limoges)	AT-03 (Attralus)	Phase 1 Clinical	Universite De Limoges	Amyloidosis	상세
ADx-001		Phase 1 Clinical	University Of Houston	Alzheimer Disease; Dementia	상세
ALZ-101	ALZ-101	Phase 1 Clinical	Alzinova AB	Alzheimer Disease; Dementia	상세
PRX-012	PRX-012	Phase 1 Clinical	Prothena	Alzheimer Disease	상세
PMN-310	huPMN-310; PMN-310	Phase 1 Clinical	ProMIS Neurosciences Inc	Alzheimer Disease; Amyotrophic Lateral Sclerosis; Multiple System Atrophy	상세
AK-152	AK152; AK-152	Phase 1 Clinical		Alzheimer Disease	상세
AA-001	AA-001; AA001	Phase 1 Clinical	Beijing Zhiyuan Hongsheng Biopharmaceutical Co Ltd	Alzheimer Disease; Cognitive Dysfunction	상세
ION-269	ION-269; ION269	Phase 1 Clinical	Ionis Pharmaceuticals Inc	Alzheimer Disease; Down Syndrome	상세
ALIA-1758	ABBV-1758; ALIA-1758	Phase 1 Clinical	Johnson & Johnson Innovative Medicine	Alzheimer Disease	상세
CM-383	CM383; CM-383	Phase 1 Clinical	Keymed Biosciences Co Ltd	Alzheimer Disease; Cognitive Dysfunction	상세
AS-603	S-603; AS-603; AS-S603	Phase 1 Clinical	Amyloid Solution Inc	Alzheimer Disease	상세
AV-1959R/AV-1980R	1959R + 1980R; AV 1959R + AV 1980R	Phase 1 Clinical	Nuravax	Alzheimer Disease	상세
Abeta42 antibody (Lilly)		Phase 1 Clinical	Eli Lilly And Company	Alzheimer Disease	상세
Anatabine citrate	RCP-006	Clinical	Rock Creek, Roskamp Institute	Alzheimer Disease; Inflammation; Smoking Cessation; Thyroiditis, Autoimmune; Tobacco Use Disorder	상세
123I-ABC-577	123I-ABC-577	Clinical	Nihon Medi-Physics Co Ltd	Diagnostic agents	상세
Tarenflurbil spraygel (MIKA Pharma)		Clinical	Galen Ltd, Mika Pharma Gmbh	Arthritis, Rheumatoid; Dermatitis, Atopic; Inflammation; Pain; Skin Diseases	상세

시판 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	가장 빠른 브랜드 이름	가장 빠른 승인 국가	가장 빠른 적응증	가장 빠른 승인 회사	가장 빠른 승인 날짜	적응증	임상 시험
Donanemab	LY-3002813-IV; LY-3002813; LY-3002813-SC	Approved	Eli Lilly And Company	Kisunla, 记能达	United States	Alzheimer Disease	Eli Lilly And Company	2024-07-02	Alzheimer Disease; Brain Diseases; Central Nervous System Diseases; Cognition Disorders; Cognitive Dysfunction; Dementia; Mental Disorders; Nervous System Diseases; Neurocognitive Disorders; Neurodegenerative Diseases; Tauopathies	상세
Flutemetamol (18F)	18F-GE067; AH-110690; GE-067	Approved	Ge Healthcare	Vizamyl	United States	Contrast agents	Ge Healthcare	2013-10-25	Alzheimer Disease; Atherosclerosis; Breast Neoplasms; Cognition Disorders; Cognitive Dysfunction; Contrast agents; Dementia; Diagnostic agents; Hydrocephalus, Normal Pressure	상세
Inositol	4L6452S749	Approved		Nicosit					Anovulation; Anxiety; Bronchopulmonary Dysplasia; Carcinoma, Non-Small-Cell Lung; Depression; Diabetic Neuropathies; Glucose Intolerance; Hyperandrogenism; Infant, Newborn, Diseases; Insulin Resistance; Lung Neoplasms; Metabolic Diseases; Polycystic Ovary Syndrome; Precancerous Conditions; Premature Birth; Retinopathy of Prematurity	상세
Immune globulin 10% (Grifols)	KIg-10; TAL-05-0002	Approved	Bayer AG	Gamunex, Gammaked	United States	Purpura, Thrombocytopenic, Idiopathic; Immunologic Deficiency Syndromes; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	null	2003-08-27	Agammaglobulinemia; Anemia, Sickle Cell; Anxiety Disorders; Autoimmune Diseases; Common Variable Immunodeficiency; Corneal Neovascularization; Coronavirus Disease 2019 (COVID-19); Immunologic Deficiency Syndromes; Kidney Failure, Chronic; Muscular Diseases; Myasthenia Gravis; Neuralgia; Obsessive-Compulsive Disorder; Pain; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating; Postural Orthostatic Tachycardia Syndrome; Primary Immunodeficiency Diseases; Purpura, Thrombocytopenic, Idiopathic; Reflex Sympathetic Dystrophy; Severe Combined Immunodeficiency; Tibial Fractures; Wiskott-Aldrich Syndrome	상세
Florapronol (18F)	18F-FC-119(S); 18F-FC-119S	Approved	Futurechem, Korea Institute Of Radiological And Medical Sciences	Alzavue					Alzheimer Disease	상세
Aducanumab	BIIB-037; NI-10; BART	Approved	Neurimmune Ag	ADUHELM	United States	Alzheimer Disease	Biogen Inc	2021-06-07	Alzheimer Disease; Cognitive Dysfunction; Dementia	상세
Procaine Hydrochloride/Vitamin B6/Inositol		Approved							Arteriosclerosis; Dyspepsia; Menopausal symptoms; Neurocirculatory Asthenia	상세
Inositol/Vitamin B1/Vitamin B2		Approved							Liver Diseases	상세
L-Lysine hydrochloride/Cyanocobalamin/Inositol		Approved		兴邦					Malnutrition	상세
Immune Globulin Subcutaneous (Human) (Octapharma)		Approved	Octapharma	Cutaquig, Octanorm, Gammanorm	United States	Immunologic Deficiency Syndromes	null	2018-08-02	Dermatomyositis; Immunologic Deficiency Syndromes; Primary Immunodeficiency Diseases	상세
Florbetaben (18F)	AV-1; ZK-6013443; BAY-949172; 18F-AV-1; MNI-815; BAY 94-9172; UNII-TLA7312TOI; 18F-AV1/ZK; AV-1/ZK	Approved	Avid Radiopharmaceuticals Inc	欧韦宁, Neuraceq	EU	Alzheimer Disease	Life Radiopharma Berlin Gmbh	2014-02-20	Alzheimer Disease; Amyloidosis; Contrast agents; Dementia; Down Syndrome; Hyponatremia; Immunoglobulin Light-chain Amyloidosis; Lewy Body Disease; Parkinson Disease; Supranuclear Palsy, Progressive	상세
Lecanemab	BAN-2401	Approved	Bioarctic Neuroscience	Leqembi, LEQEMBI, 乐意保	United States	Alzheimer Disease	Eisai Inc	2023-01-06	Alzheimer Disease; Cognitive Dysfunction; Dementia	상세
Florbetapir(18F)	MNI-798; AV-45	Approved	Eli Lilly And Company	艾美维, Amyvid	United States	Alzheimer Disease	Avid Radiopharmaceuticals Inc	2012-04-06	Alzheimer Disease; Cognitive Dysfunction; Contrast agents; Frontotemporal Dementia; Glioblastoma; Lewy Body Disease; Neurodegenerative Diseases; Parkinson Disease	상세