ALPP
ALPP 분자 정보
| 영어 이름 | Alkaline phosphatase, placental type | 시판 약물 수 | 0 |
| 임상 약물 수 | 2 | 표적 별명 | Alkaline phosphatase Regan isozyme，Placental alkaline phosphatase 1，PLAP-1 |
| 최고 연구 개발 단계 | Phase 2 Clinical | ||
| 영어 이름 | Alkaline phosphatase, placental type |
| 표적 별명 | Alkaline phosphatase Regan isozyme，Placental alkaline phosphatase 1，PLAP-1 |
| 시판 약물 수 | 0 |
| 임상 약물 수 | 2 |
| 최고 연구 개발 단계 | Phase 2 Clinical |
ALPP 제품 목록
- 속성
Protein (4)Antibody (2)
- 제품 라이브러리
온라인 (6)
- 종
Cynomolgus (1)Human (2)Mouse (2)Rat (1)
- 태그
His Tag (3)- (2)His Tag & Avi Tag (1)
- 마커
Unconjugated (5)Biotin-labeled (1)
| 제품 번호 | 종 | 발현 시스템 | 제품 설명 | 단백질 구조 | 순도 | 특성 |
|---|---|---|---|---|---|---|
HOT ALP-H52H3 |  Human | HEK293 | Human ALPP Protein, His Tag (active enzyme, MALS verified) |  |  |  |
HOT ALP-H82E3 | Human | HEK293 | Biotinylated Human ALPP Protein, His,Avitag™ (active enzyme, MALS verified) |  | | |
HOT ALP-R52H4 |  Rat | HEK293 | Rat ALPP Protein, His Tag (active enzyme) |  | | |
 Mouse | HEK293 | Monoclonal Anti-ALPP Antibody, Human IgG1 (P1H05) | | |||
| Mouse | - | Recombinant Monoclonal Anti-ALPP Antibody, Mouse (1B10) | ||||
 Cynomolgus | HEK293 | Cynomolgus ALPP Protein, His Tag (active enzyme) |  | | |
총 수량6
- 1
ALPP분자 배경
Placental alkaline phosphatase (ALPP) is a membrane-bound enzyme normally restricted to placental tissue. However, it is aberrantly overexpressed in various solid tumors, including ovarian, testicular, and cervical cancers, making it a highly specific tumor biomarker. High-affinity anti-ALPP antibodies are essential for early clinical cancer diagnostics (IHC/serum screening) and the development of targeted therapies like antibody-drug conjugates (ADCs) and CAR-T cells.
ALPP분자 별명
PLAP
임상 약물 정보
| 영어 이름 | 연구 코드 | 연구 개발 단계 | 회사 | 적응증 | 임상 시험 |
|---|---|---|---|---|---|
| Retroviral vector-transduced autologous T cells to express anti-ALPP CARs (TCRCure Biopharma Corporation) | Phase 2 Clinical | Xinqiao Hospital, Army Medical University | Endometrial Neoplasms; Ovarian Neoplasms; Solid tumours | 상세 | |
| anti-ALPP CAR T-cell therapy (TCRCure Biopharma) | TC-A101 | Phase 1 Clinical | Tcrcure Biopharma Ltd | Solid tumours | 상세 |
- 제품 목록
- 임상 약물 정보