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ALPP

ALPP Overview

English Name	Alkaline phosphatase, placental type	Approved Drugs	0
Drugs in Clinical Trials	2	Target Synonym	Alkaline phosphatase Regan isozyme，Placental alkaline phosphatase 1，PLAP-1
Highest Development Stage	Phase 2 Clinical

English Name	Alkaline phosphatase, placental type
Target Synonym	Alkaline phosphatase Regan isozyme，Placental alkaline phosphatase 1，PLAP-1
Approved Drugs	0
Drugs in Clinical Trials	2
Highest Development Stage	Phase 2 Clinical

ALPP Product List

Product Category
Protein (4)Antibody (1)
Product Status
Launched (5)
Species
Cynomolgus (1)Human (2)Mouse (1)Rat (1)
Tag
His Tag (3)- (1)His Tag & Avi Tag (1)
Conjugate
Unconjugated (4)Biotin-labeled (1)

Cat. No.	Species	Host	Product Description
HOT ALP-H52H3	Human	HEK293	Human ALPP Protein, His Tag (active enzyme, MALS verified)
HOT ALP-H82E3	Human	HEK293	Biotinylated Human ALPP Protein, His,Avitag™ (active enzyme, MALS verified)
HOT ALP-R52H4	Rat	HEK293	Rat ALPP Protein, His Tag (active enzyme)
HCS-S312	Mouse	-	Recombinant Monoclonal Anti-ALPP Antibody, Mouse (1B10)
ALP-C52H3	Cynomolgus	HEK293	Cynomolgus ALPP Protein, His Tag (active enzyme)

Total: 5

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ALPP Background

Placental alkaline phosphatase (ALPP) is a membrane-bound enzyme normally restricted to placental tissue. However, it is aberrantly overexpressed in various solid tumors, including ovarian, testicular, and cervical cancers, making it a highly specific tumor biomarker. High-affinity anti-ALPP antibodies are essential for early clinical cancer diagnostics (IHC/serum screening) and the development of targeted therapies like antibody-drug conjugates (ADCs) and CAR-T cells.

ALPP Synonyms

PLAP

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
Retroviral vector-transduced autologous T cells to express anti-ALPP CARs (TCRCure Biopharma Corporation)		Phase 2 Clinical	Xinqiao Hospital, Army Medical University	Endometrial Neoplasms; Ovarian Neoplasms; Solid tumours	Details
anti-ALPP CAR T-cell therapy (TCRCure Biopharma)	TC-A101	Phase 1 Clinical	Tcrcure Biopharma Ltd	Solid tumours	Details