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Biotinylated Mouse TNF-alpha Protein, His,Avitag™ (active trimer) (MALS verified)

인기 제품 추천: SP-11 스트렙타비딘 코팅된 96웰 플레이트  샘플 신청 
STN-N5116 스트렙타비딘 단백질  SMB-B01 스트렙타비딘 마그네틱 비드 
비오틴-스트렙타비딘 시스템의 높은 특이성과 고감도를 이용하여 비오틴화된 단백질을 스트렙타비딘 관련 제품과 결합하여 다양한 실험에서 사용할 수 있습니다. 비비오틴 시스템과 비교하면 검출이 더 빠르고 더 강력하고 더 낮은 비특이적 배경을 가지고 있습니다.
  • 동의어
    DIF,TNF-alpha,TNFA,TNFSF2,cachexin,cachectin,TNFα
  • 출처
    MABSol® Biotinylated Mouse TNF-alpha, His,Avitag (active trimer) (MALS verified) (TNA-M82E9) is expressed from human HEK293 cells. It contains AA Leu 80 - Leu 235 (Accession # P06804).
    Predicted N-terminus: Leu 80
  • 분자 표징
    Online(Leu 80 - Leu 235) P06804

    This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag.

    The protein has a calculated MW of 20.2 kDa. The protein migrates as 20-21 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 비오틴화
    비오틴화 of this product is performed using Avitag™ technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin.
  • Biotin:Protein Ratio
    Passed as determined by the HABA assay / binding ELISA.
  • 내독소
    Less than 1.0 EU per μg by the LAL method.
  • 순도

    >95% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • 레시피

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • 재구성

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 보관

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Biotinylated Mouse TNF-alpha, His,Avitag (active trimer) (MALS verified) (Cat. No. TNA-M82E9) SDS-PAGE gel

Biotinylated Mouse TNF-alpha, His,Avitag (active trimer) (MALS verified) on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS
Biotinylated Mouse TNF-alpha, His,Avitag (active trimer) (MALS verified) (Cat. No. ) MALS images

The purity of Biotinylated Mouse TNF-alpha, His,Avitag (active trimer) (MALS verified) (Cat. No. TNA-M82E9) is more than 95% in HP-SEC, and the molecular weight of this protein is around 55-70 kDa verified by SEC-MALS.

Bioactivity-ELISA
Biotinylated Mouse TNF-alpha, His,Avitag (active trimer) (MALS verified)Biotinylated Mouse TNF-alpha, His,Avitag (active trimer) (MALS verified) (Cat. No. TNA-M82E9) ELISA bioactivity

Immobilized Human TNFR1, Fc Tag (Cat. No. TN1-H5251) at 5 μg/mL (100 μL/well) can bind Biotinylated Mouse TNF-alpha, His,Avitag (active trimer) (MALS verified) (Cat. No. TNA-M82E9) with a linear range of 0.1-3 ng/mL (QC tested).

  • 백그라운드
    Tumor necrosis factor alpha (TNFα) is a cytokine produced primarily by monocytes and macrophages. It is found in synovial cells and macrophages in the tissues.The primary role of TNFα is in the regulation of immune cells. TNFα is able to induce apoptotic cell death, to induce inflammation, and to inhibit tumorigenesis and viral replication. Dysregulation of TNFα production has been implicated in a variety of human diseases, including major depression, Alzheimer's disease and cancer. Recombinant TNFα is used as an immunostimulant under the INN tasonermin. TNFα can be produced ectopically in the setting of malignancy and parallels parathyroid hormone both in causing secondary hypercalcemia and in the cancers with which excessive production is associated.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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