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ROR2

요약

Name:Tyrosine-protein kinase transmembrane receptor ROR2
Target Synonym:EC:2.7.10.1,ROR2,NTRKR2,Receptor Tyrosine Kinase Like Orphan Receptor 2,Tyrosine-Protein Kinase Transmembrane Receptor ROR2,Neurotrophic Tyrosine Kinase, Receptor-Related 2,Neurotrophic Tyrosine Kinase Receptor-Related 2,Receptor Tyrosine Kinase-Like Orphan Receptor 2,EC 2.7.10.1,BDB1,BDB
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 2 Clinical

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제품번호 종 제품 설명 구조 순도 특징
RO2-H82E3 Human Biotinylated Human ROR2 / NTRKR2 Protein, His,Avitag™
RO2-H82E3-structure
RO2-H82E3-sds
RO2-M5253 Mouse Mouse ROR2 / NTRKR2 Protein, Fc Tag
RO2-M5253-structure
RO2-M5253-sds
RO2-H52E5 Human Human ROR2 / NTRKR2 Protein, His Tag
RO2-H52E5-structure
RO2-H52E5-sds
RO2-H5251 Human Human ROR2 / NTRKR2 Protein, Fc Tag
RO2-H5251-structure
RO2-H5251-sds

일부의 생물활성 데이터

RO2-H52E5-ELISA
Human ROR2, His TagHuman ROR2, His Tag (Cat. No. RO2-H52E5) ELISA bioactivity

Immobilized Human ROR2, His Tag (Cat. No. RO2-H52E5) at 1 μg/mL (100 μL/well) can bind Anti-ROR2 Antibody, Human IgG1 with a linear range of 0.1-4 ng/mL (QC tested).

Protocol
RO2-H82E3-ELISA
Biotinylated Human ROR2, His,AvitagBiotinylated Human ROR2, His,Avitag (Cat. No. RO2-H82E3) ELISA bioactivity

Immobilized Biotinylated Human ROR2, His,Avitag (Cat. No. RO2-H82E3) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Anti-ROR2 Antibody, Human IgG1 with a linear range of 0.1-4 ng/mL (QC tested).

Protocol

Synonym Name

ROR2,NTRKR2

Background

Tyrosine-protein kinase transmembrane receptor ROR2 is also known as Neurotrophic tyrosine kinase, receptor-related 2 (NTRKR2), which belongs to the protein kinase superfamily and Tyr protein kinase family and ROR subfamily. ROR2 is a homodimer protein, which can binds YWHAB or interact with WTIP. ROR2 may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development.

Clinical and Translational Updates

임상 약품 정보

Name Research Code Research Phase Company Indications Clinical Trials
Ozuriftamab Vedotin CAB-ROR2-ADC; CAB-ADC; CAB-ROR2; BA-3021; HTBA-3021 Phase 2 Clinical Bioatla Solid tumours; Ovarian Neoplasms; Head and Neck Neoplasms; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms; Melanoma; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis Details
CCT301-59 CCT301-59 Phase 2 Clinical Bioatla, F1 Oncology Solid tumours; Carcinoma, Renal Cell; Stomach Neoplasms; Pancreatic Neoplasms; Urinary Bladder Neoplasms; Sarcoma Details

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