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FGF19

요약

Name:Fibroblast growth factor 19
Target Synonym:FGF-19
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Preclinical

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제품번호 제품 설명 구조 순도 특징
FG9-H51H3 Human Human FGF19 Protein, His Tag
FG9-H51H3-structure
FG9-H51H3-sds
FG9-H5253 Human Human FGF19 Protein, Fc Tag
FG9-H5253-structure
FG9-H5253-sds

일부의 생물활성 데이터

FG9-H51H3-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human FGF R4, Fc Tag (Cat. No. FG4-H5253) on Protein A Biosensor, can bind Human FGF19, His Tag (Cat. No. FG9-H51H3) with an affinity constant of 63.5 nM as determined in BLI assay (ForteBio Octet Red96e) (QC tested).

FG9-H51H3-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human FGF19, His Tag (Cat. No. FG9-H51H3) on HIS1K Biosensor, can bind Human FGF R4, Fc Tag (Cat. No. FG4-H5253) with an affinity constant of 16.6 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Synonym Name

FGF19/FGF-19/Fibroblast growth factor 19

Background

Fibroblast growth factor (FGF)19 is the first members of a new subfamily of FGFs and could act as hormones. During fetal life, FGF15/19 is involved in organogenesis, affecting the development of the ear, eye, heart, and brain. FGFs–FGFRs are involved in regulation of many biological processes such as embryonic development, cell proliferation, differentiation, and tissue repair. The dysregulation of FGF–FGFR  was observed in different types of diseases, disorders, and cancers. Notably, aberrant expression of FGF19/FGFR4 contributes to Hepatocellular Carcinoma progression.

Clinical and Translational Updates

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