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Your Position: > IL-7 R alpha & TSLP R

IL-7 R alpha & TSLP R

요약

Name:Interleukin-7 receptor subunit alpha
Target Synonym:Interleukin-7 receptor subunit alpha,Interleukin 7 Receptor Isoform H5-6,CDw127,IL-7R subunit alpha,IL-7RA,IL-7 receptor subunit alpha,CD127 Antigen,IL-7R-Alpha,Interleukin 7 Receptor Alpha Chain,CD127,IL7RA,ILRA,Interleukin-7 Receptor alpha Subunit
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:7
Lastest Research Phase:Phase 2 Clinical

제품 리스트 구매

Synonym Name

IL7Ra,CD127,TSLP R,CRLF2,IL-XR,ILXR,p2RY8,CRLF2 fusion,TSLP receptor,TSLPR,CRL2,CRLF2Y,Cytokine receptor-like 2

Background

TSLP is a pleiotropic cytokine originally characterized as a lymphocyte growth factor. Thymic stromal lymphopoietin (TSLP) is overexpressed in the airways of severe asthmatics and is an upstream cytokine that orchestrates inflammatory responses in asthma. Human TSLP exerts its biological activities by binding to a high-affinity heteromeric receptor complex composed of TSLPR and IL- 7 receptor and initiates signaling in cells co-expressing TSLPR and IL-7R.

Clinical and Translational Updates

임상 약품 정보

Name Research Code Research Phase Company Indications Clinical Trials
Interleukin-7 (Revimmune SAS) rhIL-7; CYT-107; CYT-99-007 Phase 2 Clinical Revimmune Inc Prostatic Neoplasms, Castration-Resistant; Neuroectodermal Tumors, Primitive, Peripheral; Catheter-Related Infections; Rhabdomyosarcoma, Alveolar; T-Lymphocytopenia, Idiopathic CD4-Positive; Leukemia, Myeloid, Acute; Metastatic breast cancer; Hepatitis C; Ureteral Neoplasms; Urologic Neoplasms; Lymphopenia; Sarcoma; Neuroblastoma; Prostatic Neoplasms; Urethral Neoplasms; Multiple Myeloma; HIV Infections; Urinary Bladder Neoplasms; Myeloproliferative Disorders; Sepsis; Carcinoma, Transitional Cell; Coronavirus Disease 2019 (COVID-19); Mycobacterium Infections, Nontuberculous; Myelodysplastic Syndromes; Rhabdomyosarcoma, Embryonal; Hepatitis B, Chronic; Carcinoma, Renal Cell; Leukemia, Myelogenous, Chronic; Kidney Neoplasms; Skin Melanoma; Shock, Septic Details
Lusvertikimab S-95011; Effi-7; OSE-217; OSE-127 Phase 2 Clinical Effimune Sjogren's Syndrome; Colitis, Ulcerative Details
Efineptakin alfa TJ-107; GX-I7; NT-I7 Phase 2 Clinical Genexine Inc Urinary Bladder Neoplasms; Sarcoma, Kaposi; Melanoma; Carcinoma, Non-Small-Cell Lung; Laryngeal Neoplasms; Leukoencephalopathy, Progressive Multifocal; Carcinoma, Squamous Cell; Glioma; Oropharyngeal Neoplasms; Gliosarcoma; Lymphopenia; Astrocytoma; Colorectal Neoplasms; Plasmablastic Lymphoma; Breast Neoplasms; Prostatic Neoplasms, Castration-Resistant; Solid tumours; Pancreatic Neoplasms; Small Cell Lung Carcinoma; Papillomavirus Infections; Hypopharyngeal Neoplasms; Lymphoma, Large B-Cell, Diffuse; Glioblastoma; Triple Negative Breast Neoplasms; Coronavirus Disease 2019 (COVID-19); Carcinoma, Merkel Cell; Esophageal Neoplasms; Squamous Cell Carcinoma of Head and Neck; HIV Infections; Ovarian Neoplasms; Lymphoma, B-Cell Details
ASP-9801 ASP-9801 Phase 1 Clinical Astellas Pharma Inc Solid tumours; Neoplasms; Neoplasm Metastasis Details
PF-06342674 RN-168; PF-6342674; PF-06342674; ZB-168 Phase 1 Clinical Pfizer Inc Diabetes Mellitus, Type 1; Multiple Sclerosis Details
Loco-regional B7H3 IL-7Ra CAR T Cell therapy(Chulalongkorn University) Phase 1 Clinical Chulalongkorn University, King Chulalongkorn Memorial Hospital Solid tumours; Neoplasms; Brain Neoplasms; Diffuse Intrinsic Pontine Glioma Details
MDK-703 MDK-703 Phase 1 Clinical Medikine Inc Solid tumours Details

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