로그인 회원가입
icon_bulk_order대량 주문 Acrobiosystems for English
0
장바구니가 비어 있습니다
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: > JAK1

JAK1

요약

Name:Tyrosine-protein kinase JAK1
Target Synonym:JAK1B,Tyrosine-protein kinase JAK1,JAK1,Janus Kinase 1,JAK1A,EC 2.7.10.2,JAK-1,JTK3,EC:2.7.10.2,EC 2.7.10
Number of Launched Drugs:8
Number of Drugs in Clinical Trials:38
Lastest Research Phase:Approved

제품 리스트 구매

제품 상태별:
제품 유형별 :
종별:
태그별:
결합물별:
제품번호 제품 설명 구조 순도 특징
JA1-H5547 Human Human JAK1 Protein, His Tag
JA1-H5547-structure
JA1-H5547-sds

Synonym Name

JAK1,JAK-1,JAK1A,JAK1B,Jak1

Background

JAK1 is a human tyrosine kinase protein essential for signaling for certain type I and type II cytokines. It interacts with the common gamma chain (?c) of type I cytokine receptors, to elicit signals from the IL-2 receptor family (e.g. IL-2R, IL-7R, IL-9R and IL-15R), the IL-4 receptor family (e.g. IL-4R and IL-13R), the gp130 receptor family (e.g. IL-6R, IL-11R, LIF-R, OSM-R, cardiotrophin-1 receptor (CT-1R), ciliary neurotrophic factor receptor (CNTF-R), neurotrophin-1 receptor (NNT-1R) and Leptin-R). Jak1 plays a critical role in initiating responses to multiple major cytokine receptor families. Expression of JAK1 in cancer cells enables individual cells to contract, potentially allowing them to escape their tumor and metastasize to other parts of the body

Clinical and Translational Updates

공개 약품 정보

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Peficitinib ASP-015K; JNJ-54781532 Approved Astellas Pharma Inc Smyraf Japan Arthritis, Rheumatoid Astellas Pharma Inc 2019-03-29 Arthritis, Rheumatoid; Psoriasis; Colitis, Ulcerative Details
Abrocitinib PF-4965842; PF-04965842 Approved Pfizer Inc Cibinqo, 希必可 United Kingdom Dermatitis, Atopic Pfizer Inc 2021-09-09 Psoriasis; Dermatitis, Atopic; Eczema; Skin Diseases, Genetic; Hypersensitivity; Hypersensitivity, Immediate; Prurigo; Hepatic Insufficiency; Granuloma Annulare; Pruritus; Food Hypersensitivity; Immune System Diseases; Skin Diseases; Skin Diseases, Eczematous; Dermatitis; Genetic Diseases, Inborn; Sarcoidosis; Kidney Diseases Details
Tofacitinib Citrate CGB-500; SSS-32; CP-690550-10; CKD-374; Tasocitinib; BI-764524; CP-690550; AC-1101; IMG 003 Approved Pfizer Inc Jakvinus, Xeljanz, 尚杰 United States Arthritis, Rheumatoid Pf Prism Cv 2012-11-06 Sarcoidosis, Pulmonary; Arthritis, Juvenile; Dry Eye Syndromes; Lung Diseases, Interstitial; Lung Diseases; Psoriasis; Lupus Erythematosus, Systemic; Granuloma Annulare; Arthritis, Psoriatic; Colitis, Ulcerative; Hepatic Insufficiency; Lupus Erythematosus, Cutaneous; Uveitis; Inflammation; Hidradenitis Suppurativa; Granulomatous Disease, Chronic; Dermatitis, Atopic; Crohn Disease; Eczema; Vitiligo; Plaque psoriasis; Diabetic Retinopathy; Lupus Erythematosus, Discoid; Non-radiographic axial spondyloarthritis; Keratoconjunctivitis Sicca; Rejection of renal transplantation; Alopecia Areata; Depression; Scleritis; Gastrointestinal Diseases; Down Syndrome; Sacroiliitis; Dermatomyositis; Alopecia; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Coronavirus Disease 2019 (COVID-19); Kidney Diseases; Spondylitis; Sjogren's Syndrome; Scleroderma, Systemic; Sarcoidosis; Glioblastoma Details
Filgotinib Maleate G-146034-101; GS-6034; G-146034; GLPG-0634 Approved Galapagos Nv Jyseleca EU Arthritis, Rheumatoid Gilead Sciences Ireland Uc 2020-09-24 Non-radiographic axial spondyloarthritis; Inflammatory Bowel Diseases; Lupus Erythematosus, Cutaneous; Arthritis, Rheumatoid; Sjogren's Syndrome; Kidney Diseases; Glomerulonephritis, Membranous; Lupus Nephritis; Colitis, Ulcerative; Arthritis, Psoriatic; Uveitis; Crohn Disease Details
Baricitinib LY-3009104; INCB-028050 Approved Incyte Corp Olumiant, 艾乐明 EU Arthritis, Rheumatoid Eli Lilly Nederland BV 2017-02-13 Diabetic Nephropathies; Polymyalgia Rheumatica; Lupus Erythematosus, Systemic; Psoriasis; Pyoderma; Coronavirus Infections; Severe Acute Respiratory Syndrome; Anhedonia; Cholangitis, Sclerosing; Conjunctivitis; Hepatic Insufficiency; Skin Ulcer; Skin Diseases, Papulosquamous; Renal Insufficiency, Chronic; Lichen Planus, Oral; Wounds and Injuries; Dermatitis, Atopic; HIV Seropositivity; Coronavirus Disease 2019 (COVID-19); Diabetes Mellitus, Type 1; HIV Infections; Alopecia Areata; Myositis; Nephritis; Depression; Dermatomyositis; Pyoderma Gangrenosum; Infections; Arthritis, Rheumatoid; Graft vs Host Disease; Pemphigoid, Benign Mucous Membrane; Skin Diseases; Liver Diseases; Arthritis, Juvenile; Lupus Nephritis Details
Ruxolitinib Phosphate INCB-018424; INC-424; INCB-424; INCB-18424 Approved Incyte Corp Jakafi, Jakavi, OPZELURA United States Primary Myelofibrosis Incyte Corp 2011-11-16 Anemia, Aplastic; Hepatomegaly; Hyperplasia; Prurigo; Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative; Lichen Planus; Leukemia, Myeloid, Chronic-Phase; Primary Myelofibrosis; Pancytopenia; Hidradenitis Suppurativa; Carcinoma, Intraductal, Noninfiltrating; Prostatic Neoplasms; Ectodermal Dysplasia; Breast Neoplasms; Leukemia, Neutrophilic, Chronic; Thrombocytosis; Coronavirus Infections; Lymphoma, Non-Hodgkin; Leukemia, Lymphocytic, Chronic, B-Cell; Myelodysplastic-Myeloproliferative Diseases; Leukemia, T-Cell; Thrombocythemia, Essential; Eczema; Vitiligo; Carcinoma, Non-Small-Cell Lung; Dermatitis, Atopic; Psoriasis; Lichen Sclerosus et Atrophicus; Carcinoma, Squamous Cell; Lymphohistiocytosis, Hemophagocytic; Lymphoma; Splenomegaly; Cachexia; Leukemia, Myeloid, Acute; Solid tumours; Myeloproliferative Disorders; Eosinophilia; Coronavirus Disease 2019 (COVID-19); beta-Thalassemia; Alopecia Areata; Lupus Erythematosus, Discoid; Squamous Cell Carcinoma of Head and Neck; Polycythemia Vera; Myelodysplastic Details
Momelotinib Dihydrochloride CYT-387; GS-0387; GSK-3070785 Approved Gilead Sciences Inc, Cytopia Pty Ltd Ojjaara United States Primary Myelofibrosis; Anemia Glaxosmithkline Llc, Glaxosmithkline Plc 2023-09-15 Polycythemia; Polycythemia Vera; Anemia; Neoplasms; Pancreatic Intraductal Neoplasms; Primary Myelofibrosis; Carcinoma, Pancreatic Ductal; Thrombocythemia, Essential; Carcinoma, Non-Small-Cell Lung Details
Upadacitinib ABT-494 Approved Abbott Laboratories, Abbvie Inc Rinvoq, 瑞福 United States Arthritis, Rheumatoid Abbvie Inc 2019-08-16 Non-radiographic axial spondyloarthritis; Alopecia Areata; Giant Cell Arteritis; Arthritis, Rheumatoid; Spondylarthritis; Spondylitis, Ankylosing; Arthritis, Juvenile; Takayasu Arteritis; Lupus Erythematosus, Systemic; Colitis, Ulcerative; Arthritis, Psoriatic; Hidradenitis Suppurativa; Dermatitis, Atopic; Crohn Disease; Vitiligo Details

임상 약품 정보

Name Research Code Research Phase Company Indications Clinical Trials
AZD-4604 AZD-4604 Phase 2 Clinical Astrazeneca Plc Asthma Details
Fingolimod/Tofacitinib FMX-114 Phase 2 Clinical Vyne Therapeutics Inc Dermatitis, Atopic Details
TT-00420/Atezolizumab Phase 1 Clinical TransThera Sciences (Nanjing) Inc Gastrointestinal Neoplasms Details
Elsubrutinib/Upadacitinib ABBV-599 Phase 2 Clinical Abbvie Inc Arthritis, Rheumatoid; Lupus Erythematosus, Systemic Details
ATI-1777 Phase 2 Clinical Aclaris Therapeutics Inc Dermatitis, Atopic Details
MAX-40070 MAX-40070 Phase 1 Clinical Maxinovel Pty Ltd Alopecia Areata Details
FZJ-003 FZJ-003 Phase 1 Clinical Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co Ltd Arthritis, Rheumatoid; Dermatitis, Atopic Details
LW-402 LW-402 Phase 2 Clinical Shanghai Longwood Biopharmaceuticals Co Ltd Arthritis, Rheumatoid; Dermatitis, Atopic Details
GLPG-3121 GLPG-3121 Phase 1 Clinical Galapagos Nv Details
LBG-1600M Phase 1 Clinical Suzhou Longbotai Pharmaceutical Co Ltd Dermatitis, Atopic Details
H-018 H018; H-018 Phase 1 Clinical Jiangsu Carephar Pharmaceutical Co Ltd, Nanjing Shenzhou Jiamei Pharmaceutical Co Ltd Arthritis, Rheumatoid Details
CS-12192 CS12192 Phase 1 Clinical Shenzhen Chipscreen Biosciences Co Ltd Enteritis; Alopecia Areata; Graft vs Host Disease; Autoimmune Diseases; Multiple Sclerosis; Lupus Erythematosus, Systemic; Dermatitis, Atopic Details
TLL-018 TLL-018 Phase 3 Clinical Tll Pharmaceutical Llc Arthritis, Rheumatoid; Chronic Urticaria; Psoriasis; Lupus Erythematosus, Systemic; Colitis, Ulcerative; Urticaria; Plaque psoriasis; Dermatitis, Atopic Details
LNK-01001 LNK001; LNK-207; EQ-121; LNK-01001; LNK01001; LNK-001 Phase 3 Clinical Lynk Pharmaceutical (Hangzhou) Co Ltd Non-radiographic axial spondyloarthritis; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Dermatitis, Atopic Details
Itacitinib INCB-039110-adipate; INCB-39110; INCB-039110; IBI-377 Phase 3 Clinical Incyte Corp Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Hemic and Lymphatic Diseases; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Breast Neoplasms; Psoriasis; Thrombocytosis; Sarcoma; Leukemia, B-Cell; Primary Myelofibrosis; Colorectal Neoplasms; Asthma; Colitis, Ulcerative; Sarcoma, Synovial; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Leukemia, Prolymphocytic, T-Cell; Lung Neoplasms; Lymphohistiocytosis, Hemophagocytic; Endometrial Neoplasms; Carcinoma, Hepatocellular; Myelodysplastic-Myeloproliferative Diseases; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis; Liposarcoma, Myxoid; Melanoma; Hodgkin Disease; Leukemia; Leukemia, Myelogenous, Chronic; Lymphoma, B-Cell; Bronchiolitis Obliterans; Head and Neck Neoplasms; Cytokine Release Syndrome; Solid tumours; Chondrosarcoma; Leiomyosarcoma; Pruritus; Polycythemia Vera; Carcinoma, Renal Cell; Hematologic Neoplasms; Myelodysplastic Syndromes; Leukemia, Myelomonocytic, Chronic; Myeloproliferative Disorders; Neoplasms; Graft vs Host Disease; Leu Details
ATI-501 A-201; ATI-501; ATI-50001 Phase 2 Clinical Rigel Pharmaceuticals Inc Alopecia Details
NIP-046 NIP-046 Phase 1 Clinical National Institutes Of Pharmaceutical Research And Development Co Ltd Arthritis, Rheumatoid Details
LNK-01002 LNK01002 Phase 1 Clinical Lynk Pharmaceutical (Hangzhou) Co Ltd Hematologic Neoplasms; Polycythemia Vera; Myeloproliferative Disorders; Primary Myelofibrosis; Leukemia, Myeloid, Acute Details
WXSH-0150 WXSH-0150; TUL-01101 Phase 2 Clinical Zhuhai United Laboratories Co Ltd Arthritis, Rheumatoid; Dermatitis, Atopic Details
Tofacitinib controlled release (Triastek) T-21; T21 Clinical Triastek Inc Colitis, Ulcerative Details
PG-018 PG-018 Phase 1 Clinical Prime Gene Therapeutics Co Ltd Nephrosis; Glomerulonephritis, Membranous Details
Povorcitinib INCB-54707; INCB54707; INCB054707; INCB-054707 Phase 3 Clinical Incyte Corp Pruritus; Renal Insufficiency; Chronic Urticaria; Kidney Diseases; Urticaria; Asthma; Prurigo; Hidradenitis Suppurativa; Angioedema; Vitiligo Details
QY201 QY-201; QY201 Phase 2 Clinical E-nitiate Biopharmaceuticals (Hangzhou) Co Ltd Alopecia Areata; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Psoriasis; Dermatitis, Atopic Details
GDC-0214 RG-6151; GDC-0214 Phase 1 Clinical Genentech Inc Asthma Details
PG-011 PG-011 Phase 2 Clinical Prime Gene Therapeutics Co Ltd Radiodermatitis; Epidermolysis Bullosa; Dermatitis; Rhinitis, Allergic; Prurigo; Eye Diseases; Dermatitis, Atopic; Vitiligo Details
AC-201 AC-201 Phase 2 Clinical Accro Bioscience (Suzhou) Co Ltd Psoriasis; Lupus Erythematosus, Systemic Details
WXFL-10203614 WXFL-10203614 Phase 3 Clinical Wuxi Fuxin Pharmaceutical Research And Development Co Ltd, Wuxi Apptec Co Ltd Arthritis, Rheumatoid; Colitis, Ulcerative; Dermatitis, Atopic Details
VR-588 VR-588; KN-002; KN-002 (Kinaset Therapeutics/Vectura) Phase 1 Clinical Vectura Ltd Asthma Details
Brepocitinib PF-06700841-15; PF-6700841; PF-841; PF-06700841 Phase 3 Clinical Pfizer Inc Alopecia; Dermatomyositis; Alopecia Areata; Kidney Diseases; Lupus Erythematosus, Systemic; Psoriasis; Colitis, Ulcerative; Arthritis, Psoriatic; Hidradenitis Suppurativa; Uveitis, Posterior; Crohn Disease; Dermatitis, Atopic; Vitiligo; Panuveitis Details
AQ-280 AQ-280 Phase 1 Clinical Aqilion AB Eosinophilic Esophagitis Details
VVN-461 VVN461e; VVN-461-e; VVN-461 Phase 2 Clinical Uveitis, Anterior; Uveitis; Inflammation; Postoperative inflammation Details
VC-005 VC-005 Phase 2 Clinical Jiangsu Vcare Pharmatech Co Ltd Inflammatory Bowel Diseases; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Joint Diseases; Colitis, Ulcerative; Dermatitis, Atopic; Vitiligo; Crohn Disease; Eczema Details
Tinengotinib TT-00420; TT 00420; TT00420 Phase 3 Clinical TransThera Sciences (Nanjing) Inc Solid tumours; Biliary Tract Neoplasms; Stomach Neoplasms; Triple Negative Breast Neoplasms; Small Cell Lung Carcinoma; Urinary Bladder Neoplasms; Cholangiocarcinoma; Prostatic Neoplasms; Breast Neoplasms; Sarcoma; Thyroid Neoplasms; Gallbladder Neoplasms Details
ATI-502 A-301; ATI-502; ATI-50002 Phase 2 Clinical Rigel Pharmaceuticals Inc Alopecia; Alopecia Areata; Dermatitis, Atopic Details

This web search service is supported by Google Inc.

totop